Colorectal Cancer (CRC), Sarcopenia
Conditions
Keywords
colorectal cancer, sarcopenia, ultrasound, bioimpedance
Brief summary
This study is aimed at clarifying changes in body composition during the perioperative period and identifying risk factors for skeletal muscle mass loss in patients with colorectal cancer. The investigators will asess the impact of the type of anaesthesia (total intravenous anaesthesia/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass, which will be evaluated using ultrasound, dynamometry and bioimpedance.
Interventions
PROCEDUREtotal intravenous anaesthesia
evaluate the impact of the type of anaesthesia (total intravenous anaesthesia (TIVA)/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass
PROCEDUREsevoflurane anaesthesia
evaluate the impact of the type of anaesthesia (total intravenous anaesthesia (TIVA)/sevoflurane anaesthesia) for colorectal surgery on the muscle function and mass
Sponsors
Regional Institute of Oncology, Iasi, Romania
Grigore T. Popa University of Medicine and Pharmacy
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• adult patients diagnosed with colorectal cancer and scheduled for open colorectal surgery at the Regional Institute of Oncology, Iaşi, Romania
Exclusion criteria
* lack the capacity to consent * extremity amputation * paraplegia * diseases affecting the muscles (such as stroke, lower-limb immobilization from a plaster, neurodegenerative diseases, peripheral neuropathy or muscle dystrophy) * terminal cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ultrasonographic assessment of muscle mass | From enrollment to 5 days after surgery | Ultrasonographic muscle assessment is standardised in the assessment of muscle according to the SARCUS (Sarcopenia through UltraSound) working group recommendations. Rectus femoris muscle will be evaluated at 50% distance between the anterior superior iliac spine and the superior pole of the patella, in a lying position with knees in 10°, for muscle thickness and muscle cross-sectional area (CSA). Three measurements will be taken for each data point, and the average value will be used for further analysis. The biceps brachii muscle will be evaluated at 50% distance acromioclavicular joint and the elbow crease, in a supine position. Muscle thickness can be easily defined as the maximal vertical distance between the superficial and deep fasciae. |
| Muscle function assessment | From enrollment to 5 days after surgery | Measuring grip strength is simple and inexpensive. Grip strength will be determined bilaterally. Each measurement will be performed three times on the left and right extremities with 20 seconds intervals between the measurements. The maximum measured value in kilograms will be used for analysis. |
| Bioimpedance assessment of lean and fat tissue mass | From enrollment to 5 days after surgery | The bioimpedance measurements will be performed by a trained operator according to the manufacturer's recommendations. The Body Composition Monitor provides a quantitative measure of lean tissue and fat tissue mass. In contrast to earlier bioimpedance methodologies, the bioimpedance spectroscopy expresses body composition as a three-compartment model, providing overhydration, lean tissue index (LTI), and fat tissue index (FTI), whereby LTI and FTI are the respective tissue masses normalized to height squared. |
Secondary
| Measure | Time frame |
|---|---|
| Hospital length of stay | From enrollment to the patient discharge, up to 52 weeks |
| Mortality | 28 and 90-day mortality after surgery |
Other
| Measure | Time frame | Description |
|---|---|---|
| Correlation | From enrollment to 5 days after surgery | Correlation between muscle strength and muscle mass using dynamometry and echography and bioimpedance at different time points |
Countries
Romania
Contacts
Primary ContactIanis Siriopol
Outcome results
None listed