Chronic Pain Predictors in Major Trauma

Risk Factors for Chronic Limb Pain in Major Trauma Patients With Limb Injury

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07237152

Acronym

COPE: MT

Enrollment

450

Registered

2025-11-19

Start date

2025-12-31

Completion date

2027-10-31

Last updated

2025-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Pain, Limb Fracture

Keywords

chronic pain, limb fracture, risk factors, prediction model

Brief summary

The goal of this observational study is to learn about who is at risk of developing chronic pain in a major trauma population with at least one limb fracture. The main question it aims to answer is: which risk factors predict which patients will experience chronic pain following traumatic limb injury. Participants will answer a baseline questionnaire and two outcome questionnaires about their pain at 3 and 6 months after their injury.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

Aged ≥ 16 Polytrauma patient (multiple injuries affecting multiple body regions or organ systems) Admitted to a UK Major Trauma Centre Minimum of 1 radiologically confirmed traumatic limb fracture Have capacity to provide informed consent to participate in the study Have sufficient proficiency in English to provide the required data or be willing to use an approved interpreting service for data collection Recruited within 4 weeks of injury

Exclusion criteria

No traumatic limb fracture Patients with a primary or treatment amputation in relation to their limb injury Pathological limb fractures Prisoners No fixed abode

Design outcomes

Primary

Measure	Time frame	Description
Presence of chronic pain	Reported at baseline, 3 and 6 months post-injury	Assessed using a 11-point numerical rating scale from 0 (no pain) - 10 (worst possible pain).
Severity of chronic pain	Reported at baseline, 3 and 6 months post-injury	Assessed using a 11-point numerical rating scale from 0 (no pain) - 10 (worst possible pain).
Pain impact	Reported at baseline, 3 and 6 months post-injury	Assessed using the six-item pain interference index

Countries

United Kingdom

Contacts

Primary ContactGeorgia E Melia, BSc (Hons), MRes

georgia.melia1@nhs.net+44 0115 9249924

Outcome results