Progression Patterns of Choroidal Venous Alterations

International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07236671

Acronym

CVA

Enrollment

250

Registered

2025-11-19

Start date

2025-03-04

Completion date

2029-08-01

Last updated

2026-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pachychoroid Disease

Brief summary

This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.

Detailed description

This study aims to document the longitudinal progression pattern and the incidence rate of progression of choroidal venous alteration (defined as either an increase in number of quadrants with pachyvessels or formation of new anastomoses which violates the physiological watershed It will provide valuable natural history data to study the pattern of evolution of choroidal vessels over time and validate the proposed multi-hit theory over a period of three years.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adults aged 45 years or older. 2. Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant. 3. Willing to undergo pupil dilation, and protocol-required procedures for both eyes 4. Willing to provide written informed consent

Exclusion criteria

1. Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period 2. Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery) 3. Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders 4. Pregnant or nursing women 5. Persons who are unable to give informed consent

Design outcomes

Primary

Measure	Time frame	Description
Progression of choroidal venous alterations	3 years	Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.

Secondary

Measure	Time frame	Description
Incidence of progression of pachychoroid disease manifestation	3 years	New onset of Central Serous Chorioretinopathy (CSCR), focal Retinal Pigment Epithelium (RPE) changes, or other pachychorois related findings.
Risk factors associated with progression of choroidal venous alteration	3 years	Assessment of demographic, cilinical, and imaging parameters associated with progression.

Countries

Hong Kong, Malaysia, Singapore

Contacts

CONTACTGemmy Cheung

gemmy.cheung.c.m@singhealth.com.sg+65 63227460

Outcome results