Traumatic Teeth, Necrotic Teeth
Conditions
Keywords
Revascularization, Grape seed extract, Glycyrrhizin
Brief summary
Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial
Detailed description
Digital count of e.faecalis before and after application of different type of intra canal medication
Interventions
Grape seed extract in form of hydrogel with concentration 6.5 % left in canal for one week
DRUGGlycyrrhizin
Glycyrrhizin hydrogel 50 micrograms in 1 milligram left in canal for one week
Trple antibiotic paste Left for one week
Sponsors
Al-Azhar University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
7 Years to 13 Years
Healthy volunteers
No
Inclusion criteria
* Healthy children aged from 7-13 years old. * Patient with necrotic pulp. * Open apex.
Exclusion criteria
. * Teeth with root fractures. * Presence of root resorptions. * Presence of periodontal pockets. * Developmental anomalies. * Tooth with class III mobility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Digital count of e.faecalis | After One week of mediation application | Microbiological evaluation The number of E. faecalis will be digitally counted. |
| Clinical evaluation success will be assessed using following criteria of success according to scoring system Absence of : - Pain, - Soft tissue swelling - soft tissue inflammation - Sinus tract - tenderness to percussion - tooth mobility | After one week of mediation application | Clincal success will be assessed using following criteria of success according to clinical scoring system Absence of : * Pain, * Soft tissue swelling * soft tissue inflammation * Sinus tract * tenderness to percussion * tooth mobility. Clinical score Clinical symptom Definition 1. asymptomatic Pathology: absent Normal functioning Mobility (physiological) ≤1mm 2. Slight discomfort, short-lived Pathology: questionable Percussion sensitivity Gingival inflammation (due to poor oral hygiene) Mobility (physiological) \> 1mm, but \<2mm 3. Minor discomfort, short-lived Pathology: initial changes present Gingival swelling (not due to poor oral hygiene) Mobility \> 2mm, but \< 3 mm 4. Major discomfort, long-lived extract immediately Pathology: late changes present Spontaneous pain Gingival swelling (not due to poor oral hygiene) Periodontal pocket formation(exudate) Sinus tract present Mobility ≥ 3mm Premature tooth loss, due to pathology |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic evaluation | After tweleve month | After tweleve months take periapical radiograph to detection normal lamina dura and increase in root thikness and length. Criteria for success according to radiographic scoring system |
Countries
Egypt
Contacts
Primary ContactMohamed Khalifa
Outcome results
None listed