Migraine, Migraine Disease
Conditions
Keywords
migraine, cognition, cognitive impairment
Brief summary
The overall objective is to define the neuropsychological profile of patients with migraine and evaluate its association with: psychological outcome measures (anxiety-depressive symptoms, pain catastrophizing, excessive worry, and coping strategies); the clinical profile of migraine; the prodromal, ictal, or interictal phase of the migraine attack; pharmacological therapy; and detoxification treatment in patients with migraine associated with medication overuse headache.
Interventions
None listed
Sponsors
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Written informed consent. * Patients aged between 18 and 65 years. * Diagnosis of migraine according to the International Classification of Headache Disorders (ICHD-3) criteria. * Patients with a history of migraine for at least one year, to ensure the stability of the condition. * Stability of ongoing treatment for at least 3 months at baseline. * Understanding of the Italian language.
Exclusion criteria
* Severe medical or psychiatric conditions (depression, schizophrenia, psychosis) documented by specific previous diagnoses. * A history of alcohol or drug abuse. * Primary sensory deficits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive functioning | 2 years | Neuropsychological test scores in migraine patients and proportion of participants with cognitive performance significantly different from age- and education-adjusted normative data. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive functions and psychological, clinical aspects | 2 years | Correlation between cognitive performance scores and validated measures of anxiety/depression, pain catastrophizing, worry, coping strategies, headache-related impact and disability, and sleep quality in migraine patients. |
| Cognitive functions and different pharmacological treatments | 2 years | Differences in cognitive test performance scores among groups of migraine patients receiving different pharmacological treatments |
| Cognitive functions and medication overuse headache | 2 years | Change in cognitive test performance scores from pre-detoxification to post-detoxification treatment in patients with migraine and medication overuse headache. |
| Cognitive functions in the different phases of migraine | 2 years | Comparison of cognitive test performance scores between ictal and interictal migraine phases and across different durations of disease. |
Countries
Italy
Contacts
PRINCIPAL_INVESTIGATORDanilo A Montisano, MD
Fondazione IRCCS Istituto Neurologico Carlo Besta
Outcome results
None listed