Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies

Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies: a Single Centre Retrospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07232771

Enrollment

200

Registered

2025-11-18

Start date

2023-01-01

Completion date

2024-12-31

Last updated

2025-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aseptic Loosening, Periprosthetic Joint Infection (PJI), Reinfection, Revision, Total Knee Arthroplasty

Keywords

Total Knee Arthroplasty, Reinfection, Aseptic Loosening, Revision, Periprosthetic joint infection (PJI)

Brief summary

A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University. This study reviewed 145 patients who underwent debridement, antibiotics, and implant retention (DAIR), 1-stage revision, 1.5-stage revision, and 2-stage revision surgeries for total knee arthroplasty periprosthetic joint infection (TKA-PJI) at this institution between 2012 and 2022. The differences in postoperative reinfection rate, microbial composition of reinfection, short-term and long-term aseptic prosthesis survival rate, prosthesis loosening and revision rate due to any cause, and long-term loosening-free survival rate among the four revision surgical approaches for TKA-PJI were evaluated, so as to provide reference value for clinical decision-making.

Detailed description

A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University. This study reviewed 145 patients who underwent debridement, antibiotics, and implant retention (DAIR), 1-stage revision, 1.5-stage revision, and 2-stage revision surgeries for total knee arthroplasty periprosthetic joint infection (TKA-PJI) at this institution between 2012 and 2022. In this study, we aimed to evaluate: (1) the postoperative reinfection rates following four surgical strategies for TKA-PJI; (2) the microbial profile of recurrent infections; (3) short- and long-term infection-free implant survival rates across the four surgical approaches; (4) re-revision rates due to aseptic loosening and long-term aseptic loosening-free implant survival rates; and (5) the reinfection rate in patients with positive cultures at the time of reimplantation. In order to provide reference value for clinical decision-making.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

1. Patients who met the diagnostic criteria for TKA-PJI; 2. Patients who underwent one of the following surgical interventions: DAIR, one-stage revision, 1.5-stage revision, or two-stage revision; 3. Patients with complete medical records available; 4. Patients who provided informed consent to participate in the study.

Exclusion criteria

1. Incomplete medical records; 2. Poor follow-up compliance, including inability to complete scheduled follow-up visits or refusal to participate in follow-up; 3. Follow-up duration less than 2 years.

Design outcomes

Primary

Measure	Time frame	Description
Infection-free survival rate	2 and 5 year after surgery	Infection-free survival rate
All-cause revision rates	5 year after surgery	All-cause revision rates
Re-revision rate	5 year after surgery	Re-revisions with implant exchange
Reinfection rate	2 and 5 year after surgery	Reinfection rate

Countries

China

Outcome results