Hypertension in Dialysis Patients
Conditions
Keywords
Intra-dialytic hypertension
Brief summary
The study is designed to diminish intra-dialytic hypertension in chrnic hemodialysis patients suffering from metabolic acidosis (low bicarbonate levels). The intervention is a tab of 500 mg sodium bicarbonate twice a day for one month, vs. placebo.
Interventions
Prescribing Sodium Bicaronate for intra-dualytic hypertension
DRUGPlacebo
1 tab X 2/day
Sponsors
Assaf-Harofeh Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Chronic hemodialysis patient \> 3 months * 3 dialysis per week, KTV\>1.2 * capable of informed concent. * rise in blood pressure during hemodialysis \> 10 mm Hg, for at least 50% of dialysis sessions in the month prior to inclusion. * Normal volume status, by clinical physician assessment + bioimpedance
Exclusion criteria
* age under 18, * pregnancy * unable to sign informed concent * planned for kidney transplant in the following 3 month. * congestive heart failure (NYHA 3-4) * hospitalization for acute MI or CHF in the past 3 months. * low compliece to medical therapy * regular pre-dialysis tests with bicarbonate \> 24 in the past 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | 1 month | Prevention of intra dialytic hypertension |
Countries
Israel
Contacts
Primary ContactShani Zilberman Itskovich, Dr.
Outcome results
None listed