Infertility Female
Conditions
Keywords
polycystic ovarian syndrome, endometriosis, female infertility,, ovarian reserve, environmental exposures, chlordecone, kepone
Brief summary
Chlordecone is an organochlorine pesticide used in the French West Indies (FWI) from 1972 to 1993 to control the banana root borer. Due to its very long persistence the population continues to be exposed to this chemical through their food consumptions. Although, chlordecone have been associated in animal study impairment of ovarian reserve, to date, no study has been published concerning the link between chlordecone exposure and female fertility. The main objective of this project is to study the association between chlordecone exposure and anti-mullerian hormone (AMH) in women consulting for couple infertility in Guadeloupe.
Detailed description
Chlordecone is an organochlorine pesticide used in the French West Indies (FWI) from 1972 to 1993 to control the banana root borer. Due to its very long persistence the population continues to be exposed to this chemical through their food consumptions. Chlordecone is an endocrine-disrupting chemical with well-defined estrogenic and progestagenic properties in vivo and in vitro. To date, no study has been published concerning the link between chlordecone exposure and female fertility. Nevertheless, mammalian studies in females have consistently reported that chlordecone exposure impairs ovulation and leads to a reduced ovarian reserve. In addition, there are questions about the impact of other environmental exposures, including by non-targeted approaches, and also of the vaginal and endometrial microbiome on female fertility.
Interventions
None listed
Sponsors
Institut Pasteur de Guadeloupe
Rennes University Hospital
Centre Hospitalier Universitaire de la Guadeloupe
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
No
Inclusion criteria
* Women aged from 18 to 39 years * Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe * Free, informed and written consent
Exclusion criteria
* Women aged from 18 to 39 years * Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe * Free, informed and written consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Levels of AMH according to terciles of chlordecone levels. | AMH levels will be measured during the assessment conducted for assisted reproductive technology (ART) and will date from less than one year before inclusion | The purpose is to study the association between chlordecone exposure and AMH levels in women consulting for couple infertility in Guadeloupe. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of antral follicles according to terciles of chlordecone levels. | between days 2 and 4 of the spontaneous menstrual cycle | Transvaginal ultrasound for antral follicle count will be performed between days 2 and 4 of the spontaneous menstrual cycle, the number of antral follicles corresponds to the total number of antral follicles in both ovaries, with a diameter between 2 and 10 mm. |
| AMH levels and antral follicle count according to the levels of other POPs | baseline | AMH levels and antral follicle count |
| relationship between exposure to chlordecone and other POPs and the risk of the main causes of female infertility | baseline | main causes of female infertility : Endometriosis ; Polycystic ovary syndrome (PCOS) ; Decreased ovarian reserve |
| Chlordecone levels according to the outcomes of IVF/ICSI management: | changes from baseline to 2 years after | relationship between occupational exposure to solvents and others factors described : * Endometrial thickness, * Peak estraiol, * Number of oocytes collected, * Number of mature oocytes collected, * Number of zygotes, * Embryo quality, * Blastocyst number, * Number of frozen embryos, * Biological pregnancy, * Clinical pregnancy, * Live birth. |
Countries
Guadeloupe
Contacts
Primary ContactMélanie petapermal
Backup ContactValérie Hamony Soter
Outcome results
None listed