Coronary Heart Disease (CHD), Ischemic Mitral Regurgitation
Conditions
Brief summary
This project will rely on the established multi-center cooperation platform for total valve disease and based on the Carpentier classification, which is newly proposed and widely recognized by the academic community, and will specifically target the population with coronary heart disease combined with Ischemic Mitral Regurgitation（IMR） to conduct a nationwide, multi-center, single valve disease, prospective cohort. Research. From November 2025 to December 2025, 6,000 patients with coronary heart disease combined with moderate or above IMR were consecutively selected from outpatients or inpatients in 21 regional medical centers across the country, and clinical characteristics, imaging data, and serology were collected. Information, drug/surgical intervention status and clinical outcome indicators were included in the clinical follow-up at baseline, 3 months, 6 months, 12 months and 24 months respectively. The main research objectives are to describe the disease characteristics, treatment status and clinical outcomes of coronary heart disease patients with IMR; to evaluate the current application status of GDMT strategies in IMR diagnosis and treatment practice and its impact on mid- and long-term prognosis. The secondary research objectives are to identify factors affecting prognosis, construct a risk stratification model for mid- and long-term prognosis, and discover new molecular markers. This project will for the first time construct the world's largest clearly defined cohort of coronary heart disease combined with IMR. Its research results can provide high-quality data and decision-making basis for precise diagnosis and treatment of IMR populations. Therefore, this project has important scientific research value and clinical guidance significance.
Interventions
None listed
Sponsors
China National Center for Cardiovascular Diseases
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years, secondary mitral regurgitation discovered during outpatient visit or hospitalization; * Have definite coronary heart disease * Cardiac ultrasound: consistent with mitral regurgitation caused by myocardial ischemia or myocardial infarction: 1. Segmental wall motion abnormality or 2. Mitral regurgitation is consistent with Carpentier type IIIb (eccentric regurgitation) * Cardiac ultrasound prompts: moderate or above ischemic mitral regurgitation
Exclusion criteria
* Patients within the past year or currently participating in other clinical studies; * Primary mitral regurgitation (such as mitral valve prolapse, perforation, chordae tendineae rupture, etc.); * Dilated cardiomyopathy, hypertrophic cardiomyopathy and other diseases; * Moderate and above aortic stenosis/regurgitation, mitral stenosis, tricuspid stenosis, etc.; * Patients who have undergone cardiac valve intervention/surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Composite endpoint of heart failure hospitalization and all-cause death | 3, 6, 12, 24 months | Time to first occurrence of either hospitalization for heart failure or death from any cause, whichever occurs first. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in mitral regurgitation severity | 3 month, 6 month, 12 month, 24 month | Change in mitral regurgitation (MR) grade from baseline to 24 months as assessed by echocardiography, measured using standard semiquantitative grading (none, mild, moderate, severe). |
| All-cause mortality | 3 month, 6 month, 12 month, 24 month | Incidence of death due to any cause during the follow-up period |
| Hospitalization for heart failure | 3, 6, 12, 24 months | Incidence of unplanned hospital admission primarily for management of heart failure symptoms. |
Contacts
Primary ContactErli Zhang, MD, PhD
Outcome results
None listed