Brain Imaging
Conditions
Brief summary
This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).
Detailed description
A battery of tasks will be performed under two imaging conditions. Magnetic Resonance Imaging and transcranial functional ultrasound imaging. Tasks include a breath hold task, an e-stim task, and low-intensity focused ultrasound neuromod.
Interventions
DEVICEFeasibility of imaging using tFUS
Imaging using transcranial functional ultrasound.
Sponsors
Virginia Polytechnic Institute and State University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY
Masking
NONE
Intervention model description
All participants will complete all study visits - fMRI + tasks, tFUS + tasks, and tFUS + LIFU.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* See above.
Exclusion criteria
* Claustrophobia * Contraindications to MRI (neurostims, metal implants, pacemakers, etc) * Contraindications to CT (pregnancy) * Active medical disorders with CNS effects (e.g. Alzheimers) * History of neurological disorder * History of head injury with LOC \> 10 min * History of alcohol or drug dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detecting task-evoked changes | The duration of each task - ~10 minutes. | Detecting task-evoked changes using tFUS imaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Detecting LIFU induced neural activity | During LIFU application, ~2 min. | Detection in changes of neural activity during LIFU using tFUS |
Countries
United States
Outcome results
None listed