Carotenoids in the Skin and Immune Aging

Carotenoids in the Skin and Immune Aging: a Pilot Observational Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07221643

Enrollment

Registered

2025-10-28

Start date

2025-10-09

Completion date

2026-04-01

Last updated

2025-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

No Condition, Skin Carotenoids and Immune-aging

Brief summary

This study aims to examine the connection between the level of carotenoids in the skin and a number of immune related health parameters.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Willing and able to provide written informed consent * Age 18-30 years OR 65 years and older * Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed) * Fiitzpatrick I-VI (all skin types)

Exclusion criteria

* Pregnant or breastfeeding * uncontrolled medical conditions * Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis * Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others) * Unable to follow study protocol

Design outcomes

Primary

Measure	Time frame	Description
Skin carotenoid levels and skin aging features	one day	We will assess the skin carotenoid levels' correlation with skin aging features, such as wrinkles, fine lines, and age spots.

Secondary

Measure	Time frame	Description
Skin carotenoid levels and biomarkers of aging	one day	We will assess the skin carotenoid levels' correlation with biomarkers associated with aging, such as C-reactive protein, telomere length, telomerase activity etc.
Skin carotenoid levels and self-reported perception of health	2 weeks	We will assess the skin carotenoid levels' correlation with self reported scores on general health and health beliefs, incidence of respiratory, gut and skin allergy symptoms, and sleep quality.

Countries

United States

Contacts

Primary ContactXiaochen Zhong, BA

xczhong@stanford.edu408-816-0111

Backup ContactPo-Han Ho, MD

pohanho@stanford.edu

Outcome results