Healthy Participants
Conditions
Brief summary
Our primary goal is to investigate the role of Low-Intensity Focused Ultrasound (LIFU) neuromodulation on deep brain targets, and its potential to improve cognition
Interventions
DEVICELow-Intensity Focused Ultrasound (FUS or LIFU)
We will use an established, currently-marketed device to deliver LIFU neuromodulation.
Sponsors
University of Minnesota
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 18 years of age or older * Speak English (as assessed by their ability to read/answer survey questions) * May be required to score in the appropriate range on self-report measures
Exclusion criteria
* They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults. * They take any psychoactive medication. * They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder. * Are pregnant, or may have reason to believe that they are pregnant. * They have a diagnosis of a psychiatric condition other than depression or anxiety
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Deep Brain Targets Reached | Hour 1 | MRI-based readouts testing whether LIFU neuromodulation can successfully engage targets in deep brain |
| Multi-Source Interference Test (MSIT) Performance | Hour 1 | Behavioral readouts of successful LIFU neuromodulation of our target regions |
| 28/Posit Science Performance | Hour 1 | Behavioral readouts of successful LIFU neuromodulation of our target regions |
Countries
United States
Contacts
CONTACTMiriam Freedman
PRINCIPAL_INVESTIGATORMichael Bronstein
University of Minnesota
Outcome results
None listed