Musculoskeletal Pain - Acute and Subacute Conditions
Conditions
Keywords
Rehabilitation, Biomechanics, Early Mobilization, Movement Therapy, Functional Recovery, Pain Management, Physical Therapy
Brief summary
A Prospective, Multi-Site, Interventional Case-Series Evaluating the MOVE (Movement-Oriented Velocity of Engagement) Protocol for Musculoskeletal Pain Recovery
Detailed description
The MOVE Protocol is a structured, biomechanics-based rehabilitation framework designed to accelerate recovery from musculoskeletal pain conditions through progressive mobilization and neuromuscular control. This interventional case-series involved multiple clinical and training centers (BodyGNTX, GFFI, IIKBS, ASFU) and applied standardized MOVE sessions under the supervision of certified movement specialists. Assessments included pain scoring (NRS), functional mobility (LEFS/UEFI), and balance control, measured at baseline, week 2, week 4, and week 8. The protocol followed ICH-GCP E6(R2) and Helsinki 2013 guidelines, with institutional ethics approval from MMSx Authority IREB. The study demonstrated safe and effective early-movement outcomes across diverse populations, emphasizing mobility, load optimization, and neuromuscular revalidation.
Interventions
BEHAVIORALMOVE Rehabilitation Protocol
The MOVE (Movement-Oriented Velocity of Engagement) protocol is a biomechanics-based rehabilitation approach targeting early mobilization and functional recovery for musculoskeletal pain conditions. The structured program includes four key phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery, applied over 8 weeks under therapist supervision.
Sponsors
MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.
Indian Institute of Kinesiology and Biomechanics Science (IIKBS)
BodyGNTX Fitness Institute
ASFU (American Sports & Fitness University)
GFFI Fitness Academy
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
Open-label rehabilitation study. Both investigators and participants were aware of the intervention procedures, as exercise-based protocols require therapist supervision and participant engagement.
Intervention model description
This was a multi-site, single-arm interventional case-series evaluating the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation protocol for acute and subacute musculoskeletal pain. Forty participants across four international centers completed an 8-week standardized intervention consisting of four progressive phases: Mobilize, Optimize Load, Validate Neural Control, and Energize Recovery. The study aimed to assess safety, functional recovery, and pain reduction outcomes following the MOVE protocol.
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* • Adults aged 18-65 years diagnosed with acute or subacute musculoskeletal pain or movement restriction (≤12 weeks duration). * Capable of performing supervised rehabilitation and daily movement tasks. * Able to provide informed consent and comply with study assessments. * Baseline pain score ≥4 on the Numerical Rating Scale (NRS).
Exclusion criteria
* Chronic pain (\>12 weeks) or neurological disorders affecting movement control. * Post-surgical cases or fractures within the past 3 months. * Cardiopulmonary or systemic illness contraindicating exercise participation. * Pregnancy or conditions limiting safe participation in physical rehabilitation. * Refusal to sign informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain Reduction (NRS Score) | Baseline, Week 2, Week 4, and Week 8 | Change in Numeric Rating Scale (NRS) for pain intensity from baseline to week 8 following the MOVE (Movement-Oriented Velocity of Engagement) rehabilitation program. Participants rated pain on a 0-10 scale where 0 = no pain and 10 = worst possible pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional Improvement (LEFS / UEFI Score) | Baseline, Week 2, Week 4, Week 8 | Change in Lower Extremity Functional Scale (LEFS) or Upper Extremity Functional Index (UEFI) from baseline to week 8, reflecting mobility and activity performance improvement post-MOVE intervention. |
| Balance and Postural Stability (Timed Single-Leg Stance Test) | Baseline, Week 4, Week 8 | Improvement in single-leg stance duration and balance control across sessions as measured by standardized postural tests. |
| Participant Perceived Recovery (Global Rating of Change Scale) | Week 8 | Participants rate overall improvement on a 7-point Global Rating of Change (GROC) scale at week 8 to capture subjective recovery perception. |
Countries
India, United States
Outcome results
None listed