Genitourinary System Carcinoma, Malignant Pelvic Neoplasm
Conditions
Brief summary
This study is being done to see if researchers can find a better way to image a patient's tumor during radiation treatment.
Interventions
OTHERNon-Interventional Study
Non-interventional study
Sponsors
University of Michigan Rogel Cancer Center
Varian Medical Systems, Inc.
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \* Patients with pelvis or genitourinary (GU) cancer requiring standard of care radiotherapy treatment * All adults, defined as individuals of 18 years of age or greater * Radiotherapy treatment will be performed on the Varian Ethos radiotherapy system * Ability to understand and the willingness to sign a written informed consent
Exclusion criteria
* \* Minors, defined as individuals less than 18 years of age * Pregnant or nursing female
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Image quality- Mean | Up to 2 years | The primary analysis will compare imaging quality endpoints processed by DE-CBCT and the standard of care SE-CBCT, with the latter representing the standard clinical acquisition. Descriptive statistics will be computed for the image quality metrics from each imaging modality and for the difference in metrics between the modalities. A paired t-test or Wilcoxon signed-rank test will compare the distribution of the image quality metrics between DE-CBCT and standard of care SE-CBCT. Secondary analysis will compare image quality endpoints between DE-CBCT and standard of care conventional planning CT. |
| Image quality- median | Up to 2 years | The primary analysis will compare imaging quality endpoints processed by DE-CBCT and the standard of care SE-CBCT, with the latter representing the standard clinical acquisition. Descriptive statistics will be computed for the image quality metrics from each imaging modality and for the difference in metrics between the modalities. A paired t-test or Wilcoxon signed-rank test will compare the distribution of the image quality metrics between DE-CBCT and standard of care SE-CBCT. Secondary analysis will compare image quality endpoints between DE-CBCT and standard of care conventional planning CT. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORRobert Dess
University of Michigan Rogel Cancer Center
Outcome results
None listed