Liver Transplant, Post Transplant Diabetes, Type 2 Diabetes
Conditions
Keywords
liver transplant, hyperglycemia, diabetes, continuous glucose monitoring, glucose sensor
Brief summary
This investigator initiated study aims to describe continuous glucose monitoring (CGM) based glycemic metrics after discharge from liver transplant and assess relationship with glycemic metrics and liver transplant outcomes.
Detailed description
Liver transplant participants will be recruited. Participants will wear a blinded sensor after hospital discharge for up to 30 days. Data can be shared with participant and the providers retrospectively. Participants will be invited to wear another blinded sensor at 6 and 12 months.
Interventions
DEVICELibre 3+
Blinded CGM will be worn by all participants
Sponsors
Icahn School of Medicine at Mount Sinai
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• inpatient liver transplant participants who have had an inpatient glucose greater than 180mg/dL
Exclusion criteria
* having a planned discharge to a rehabilitation or nursing facility, * a contraindication to sensor placement, * if discharge is anticipated to be \>30 days post-transplant, or * if recent transplant also included a kidney or pancreas transplant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time in range | 28 days | Time in range 70-180mg/dL |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percent time >180mg/dL | 28 days | Percent time \>180mg/dL |
| Percent time >250mg/dL | 28 days | Percent time \>250mg/dL |
| Percent time <70mg/dL | 28 days | Percent time \<70mg/dL |
| Percent time <54mg/dL | 28 days | Percent time \<54mg/dL |
| Transplant outcomes | 1 year | Rate and time to of wound complications, vascular complications, biliary complications, acute kidney injury, transplant rejection, and readmissions |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORGrenye O'Malley, MD
Icahn School of Medicine at Mount Sinai
Outcome results
None listed