Human Immune Response
Conditions
Keywords
Palmar Cooling, Human Immunology, Exercise Immunology
Brief summary
This is a research study on human exercise that will investigate the immune system response post-exercise and how it relates to Delayed Onset Muscle Soreness (DOMS), and possible causes for DOMS. Blood draws (10mL) will be obtained at 5 timepoints: Baseline before intervention, day of exercise immediately following exercise, and post-exercise days 1, 2 and 4. Point of care lactate levels obtained before and after exercise. Subjective pain scores recorded daily starting immediately after after exercise.
Interventions
OTHERMuscle Temperature Control
The intervention will be placing the palms of the hands on a water perfused pad.
Sponsors
Wu Tsai Human Performance Alliance
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Control arm has palmar temperature device set to 30 degrees celsius, interventional arm has palmar temperature device set to 14 degrees celsius.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- Ability to perform two arm bicep curl of at least 35 lb as 1 repetition maximum
Exclusion criteria
* Autoimmune disease * Steroid use * On current immune-modifying treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean change from baseline in phosphorylation markers in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and Toll-like Receptor (TLR)-pathway in immune cell populations | From enrollment to 5 days after the end of treatment | Collected at baseline from whole blood prior to exercise, day of exercise, post-exercise day 1, post-exercise day 2, post-exercise day 4 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from pre-exercise baseline in point of care lactate levels | 1 day | Two point of care lactate draws before and after exercise obtained in mmol/L |
| Change in Pain Scores from baseline | From day of intervention daily for 5 days. | Daily subjective pain scores recorded according to the Borg Perceived Pain Scale from 0 (no pain) to 11 (maximum pain) |
Countries
United States
Outcome results
None listed