All-cause Death, Calcified Plaque, Cardiovascular Death, CT Plaque, FFR-CT, Non-calcified Plaque, Nonfatal Myocardial Infarction, Nonfatal Stroke, Stroke (Subacute)
Conditions
Keywords
CTCA, CT, Coronary CT, Calcium Score, Plaque, Coronary Artery Disease, CAD, Chest pain
Brief summary
The study aims at determining if the presence of adverse plaque features identified from the CT angiogram can help determine prognosis and guide treatment options.
Interventions
DIAGNOSTIC_TESTCTCA
Patient who is ≥ 18 years old presented with chest pain and has undergone CTA between 01-Jan-2012 and 31-Dec-2022 before treatment \- If multiple CTAs are taken, the most updated one before treatment commencement will be chosen.
Sponsors
The University of Hong Kong
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Inclusion criteria
* Patient who is ≥ 18 years old presented with chest pain and has undergone CTA between 01-Jan-2012 and 31-Dec-2022 before treatment * If multiple CTAs are taken, the most updated one before treatment commencement will be chosen.
Exclusion criteria
* Patient who did not undergo cardiac CT scan due to inability to undergo cardiac CT scanning, kidney failure (serum creatinine \>250 μmol/L or estimated glomerular filtration rate \<30 mL/min), major allergy to contrast.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death and all-cause death | 5 years after CTCA examinations |
Secondary
| Measure | Time frame |
|---|---|
| Total plaque (mm³) to predict cardiac events | 5 years after CTCA examinations |
| Calcified plaque (mm³) to predict cardiac events | 5 years after CTCA examinations |
| Non-calcified plaque (mm³) to predict cardiac events | 5 years after CTCA examinations |
| CT-FFR to predict cardiac events | 5 years after CTCA examinations |
Countries
Hong Kong
Outcome results
None listed