Hemoptysis, NEBULIZATION, Tranexamic Acid
Conditions
Keywords
Hemoptysis, Nebulization, tranexamic acid
Brief summary
This study compares the effect of tranexamic acid on hemoptysis when given through the conventional IV route and Through nebulization.
Detailed description
The investigators are conducting a randomized controlled trial for the comparison of routes through which tranexamic acid can be given to control hemoptysis. The study participants will be divided into 2 groups randomly and 1 group will be assigned to use IV route while other will be assigned the nebulization route and the result variables include the time taken for complete control of hemoptysis and recurrence time. Another variable is the reduction in amout of blood in sputum after each intervention.
Interventions
DRUGTranexamic Acid (TXA)
In this study we are comparing the effect of tranexamic acid on hemoptysis when given through IV route and nebulization
Sponsors
University of Health Sciences Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
There is no masking as the participnats will be explained the whole process and consent would be taken for using the either route for administration of tranexamic acid
Intervention model description
The intervention will be given to the participants via providing the tranexamic acide through both IV and nebulization routes.
Eligibility
Sex/Gender
ALL
Age
12 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with mild to moderate hemoptysis \< 600ml/ 24 hours of age 12 to 80 years and both genders. 2. Patients with hemoptysis due to infective pathology. 3. Patients with hemoptysis due to malignant pathology.
Exclusion criteria
1. Patients on antiplatelet therapy or aspirin 2. Hemoptysis after penetrating lung injury e.g. firearm injury 3. Patients with history of asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to control hemoptysis | 48 hours | In this study the time taken by tranexamic acid to acehive comolete control of hemoptysis will be compared when given through IV and nebulization. |
Countries
Pakistan
Outcome results
None listed