CLABSI - Central Line Associated Bloodstream Infection, Peripherally Inserted Central Catheter, Umbilical Venous Catheter
Conditions
Brief summary
This study aims to prospectively compare umbilical venous catheters (UVCs) and peripherally inserted central catheters (PICCs) in neonates, focusing on complications, catheter survival, and central line-associated bloodstream infection (CLABSI) rates
Interventions
PROCEDUREperipherally inserted central catheter insertion
Neonates who received peripherally inserted central catheters within the first 28 days of life.
PROCEDUREumbilical venous catheters insertion
Neonates who received umbilical venous catheters within the first 28 days of life
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Days to 28 Days
Healthy volunteers
No
Inclusion criteria
* Neonates admitted to the neonatal intensive care unit (NICU) requiring central venous access. * Infants in whom either an umbilical venous catheter (UVC) or a peripherally inserted central catheter (PICC) was inserted for clinical indications (Parenteral nutrition, administration of intravenous medications (e.g., antibiotics, inotropes, anticonvulsants, fluids) and blood sampling for frequent labs, especially in critically ill neonates). * Catheter insertion performed within the first 28 days of life.
Exclusion criteria
* Neonates with major congenital anomalies (e.g.abdominal wall defects) that may interfere with catheter placement or outcomes. * Insertion site infection * Infants with severe coagulopathy or bleeding disorders contraindicating central catheter insertion. * Neonates who received both UVC and PICC simultaneously during the same admission. * Cases with incomplete clinical records or missing follow-up data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| catheter survival time | From catheter insertion until removal (up to 28 days of life or until hospital discharge, whichever occurs first) | Number of days each catheter remains functional and in use before removal |
| Central Line-Associated Bloodstream Infection (CLABSI) Incidence | During the entire catheterization period (up to 28 days of life or until hospital discharge | Number of CLABSI events per 1,000 catheter-days, diagnosed according to CDC/NHSN criteria (positive blood culture + clinical signs of sepsis with no other source) |
Outcome results
None listed