Breast Carcinoma
Conditions
Brief summary
The purpose of this research is to better understand how benign breast diseases might lead to breast cancer, focusing on genetic factors and including a diverse range of participants to improve future diagnosis and treatment.
Interventions
OTHERNon-Interventional Study
Non-interventional study
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Female patients, ages 18 to 100 years * Had a benign breast biopsy at Mayo Clinic between 2002-2022
Exclusion criteria
* All male patients * Prior or concomitant diagnosis of BC * Diagnosis of BC within six months of benign breast disease * Denial of research authorization * Concurrent or post-biopsy bilateral prophylactic mastectomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pathologic features | Baseline (collection of blood or saliva sample) | Will examine pathologic features from benign tissue to define features related to breast cancer (BC) risk. |
| Radiologic features | Baseline (collection of blood or saliva sample) | Will examine radiologic features from mammographic images at time of benign breast disease (BBD) to define features in mammogram images that predict BC risk among women who have a history of BBD. We will also assess whether these features predict BC risk among women without a history of BBD. |
| Molecular features | Baseline (collection of blood or saliva sample) | Will examine molecular features to understand how molecular features, including DNA damage and repair work in the breast tissues of women with BBD and how this might relate to risk of developing BC |
Countries
United States
Contacts
CONTACTLaura Pacheco-Spann
CONTACTClinical Trials Referral Office
PRINCIPAL_INVESTIGATORMark E. Sherman, MD
Mayo Clinic
Outcome results
None listed