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Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid

Effect of Low-Level Laser Therapy Versus Hyaluronic Acid on Wound Healing After First Permanent Molar Extraction in Children.

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07205640
Acronym
LLLT vs HA
Enrollment
36
Registered
2025-10-03
Start date
2025-12-01
Completion date
2026-12-01
Last updated
2025-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Badly Decayed Molars, Extraction Socket Healing, Healthy Volunteer, Hyaluronic Acid Gel for Preservation the Extraction Socket, Low Level Laser Therapy, Mesh, Tooth Extraction Site Healing

Keywords

hyaluronic acid, low level laser therapy, tooth extraction

Brief summary

Tooth extraction may be an unpleasant and painful experience for children, Post-extraction wound healing. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing, resulting in both an increase in cell number and an increase in cell metabolism. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues.

Detailed description

Tooth extraction may be an unpleasant and painful experience for children. Pain felt during dental treatment, especially tooth extraction, is the most common complication. Pain management during and after tooth extraction is part of behavioral guidance, especially in pediatric patients. Post-extraction wound healing and pain perception are related to hostrelated factors such as the patient's immune system, the use of painkillers and antibiotics, the presence of infection in the region, and the atraumatic nature of the procedure. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing. It is based on the idea that exposure to a specific wavelength can alter cellular behavior, resulting in both an increase in cell number and an increase in cell metabolism. Aside from not having any negative effects, LLLT is an a thermic, photobiological, and nondestructive therapy approach. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues. Among the many biological effects of HA are its functions in cell differentiation, wound healing, inflammation, embryological development, and viscoelasticity.

Interventions

DEVICELow-Level Laser Therapy

A 980 nm diode laser will be applied immediately after extraction of the first permanent molar. The laser will be used in continuous mode at 0.5 W, with a total energy of 300 J, applied for 60 seconds at three points around the extraction socket.

DRUGHyaluronic Acid (HA)

Hyaluronic acid gel will be applied directly into the extraction socket immediately after tooth removal.

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Masking description

outcome assessors and statistician

Eligibility

Sex/Gender
ALL
Age
6 Years to 10 Years
Healthy volunteers
Yes

Inclusion criteria

1. Children aged from six to ten years. 2. Children of both genders. 3. Children with badly decayed first permanent molar beyond repair and indicated for extraction. 4. Parents acceptance to participate in the study.

Exclusion criteria

1. Medically compromised children. 2. Uncooperative children. 3. Children who will not attend the follow up visits

Design outcomes

Primary

MeasureTime frameDescription
wound size7 daysWound size unit of measure : mm (millimeters) (mesiodistal and buccolingual dimension of each socket).

Secondary

MeasureTime frameDescription
Tissue Color ChangesDay 0, Day 3, and Day 7 post-extraction.Gingival color assessed using the Landry, Turnbull, and Howley Index (normal vs inflamed). Unit of Measure: Binary (normal / inflamed)
Bleeding Upon PalpationDay 0, Day 3, and Day 7 post-extraction.Presence or absence of bleeding when palpating the extraction site. Unit of Measure: Binary (yes / no)
Pus PresenceDay 0, Day 3, and Day 7 post-extraction.Presence or absence of pus at the extraction site. Unit of Measure: Binary (yes / no)
Pain Level During ApplicationImmediately after intervention (Day 0).Pain assessed using Wong-Baker Faces Pain Rating Scale (0 = no pain, 10 = worst pain). (0 = no pain, 10 = worst pain). Higher scores indicate worse outcomes.

Countries

Egypt

Contacts

Primary ContactMona Ali Abd Elhafiz, BDS
info@cu.edu.eg+201000323801
Backup ContactMona Ali AbdelHafiz, BDS
mona.ali@dentistry.cu.edu.eg+201000323801

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026