Deprescribing, Elderly (People Aged 65 or More), Hospitalization, Polypharmacy (People Under Treatment With 5 or More Drugs)
Conditions
Keywords
polypharmacotherapy, interactions, elderly people, STOPP&START CRITERIES, DEPRESCRIBING
Brief summary
Evaluate the prevalence of potentially inappropriate prescriptions (PIPs) and potential omitted prescriptions (PPOs) in elderly patient upon admission to the acute geriatric department, based on adherence or non-adherence to the recommendations specified in STOPP and START criteria.
Interventions
The study protocol includes the following assessments: * T0: first data collection upon admission to the ward; * T1 assessment: pharmacological review at discharge. Subjects who meet all study eligibility criteria will come consecutively enrolled in the study during admission to the department (T0). By consulting the electronic health record, interviewing patients and family members and personal documentation, the following data will be collected: * Remote and immediate pathological history; * Family and social history; * Home therapy; * BRIEF-MPI. Home therapy and therapy suggested at discharge will be compared with the STOPPandSTART criteria to evaluate the prevalence of potential therapies inappropriate and to study possible interactions and contraindications pharmacological and for reporting possible adverse reactions to drugs. The prevalence and possible prevalence of each individual STOPPandSTART criterion will be assessed association with other variables of interest.
Sponsors
Regione del Veneto - AULSS n. 7 Pedemontana
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
75 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Elderly patients (aged \>75 years) admitted to the Geriatrics Department at Santorso, Alto Vicentino Hospital. * Currently undergoing pharmacological treatment at the time of admission.
Exclusion criteria
• Patients placed in palliative therapy upon admission to the department due to incurability of the underlying pathologies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Potentially Inappropriate Prescriptions (PIP) (%) | Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4 | Percentage of elderly patients with at least one potentially inappropriate prescription identified at hospital admission (day 0) and at discharge (day 1) in the acute geriatric ward, based on the STOPP criteria. The measurement is performed by comparing the patient's medication regimen with the recommendations provided in the STOPP criteria. |
| Prevalence of Potentially Omitted Prescriptions (PPO) (%) | Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4 | Percentage of elderly patients with at least one potentially omitted prescription identified at hospital admission (day 0) and at discharge (day 1) in the acute geriatric ward, based on the START criteria. The measurement is based on the absence of indicated medications according to the START criteria recommendations. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of Pharmacological Interactions (%) | Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4 | Percentage of patients with at least one clinically significant drug-drug interaction identified through analysis of the medication regimen using standard drug interaction checkers. Assessed at admission and discharge. |
| Post-Discharge Destination (Binary Variable) | Data collected at time Day 0 is analyzed by day 4. | Discharge destination classified as a binary variable (e.g., Home vs. Institutional care). Each category is analyzed separately. |
| Presence of Geriatric Syndromes (Yes/No) | Data collected at time Day 0 is analyzed by day 4. | Presence of specific geriatric syndromes (e.g., delirium, falls, incontinence, pressure ulcers, etc.) assessed as separate binary variables (Yes/No) for each syndrome, based on clinical records and standardized assessment tools. |
Countries
Italy
Outcome results
None listed