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Procedural Complications and Long-Term Mortality in Complex Coronary Interventions

The Impact of Procedural Complications on Long-Term Mortality in Complex Coronary Interventions: The Multicenter COMPLEX-ANATOLIA Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07202754
Enrollment
20000
Registered
2025-10-02
Start date
2026-05-13
Completion date
2026-07-07
Last updated
2026-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complex Coronary Artery Disease

Keywords

Complications, death, major adverse cardiac events, target vessel revascularization

Brief summary

The relative risks for different non-fatal intraprocedural complications during complex percutaneous coronary intervention (PCI) on subsequent mortality have not been described. This study aimed to assess the association between non-fatal intraprocedural complications and late mortality after complex coronary PCI.

Detailed description

Complex coronary lesions include chronic total occlusion, osteal epicardial lesions, long (diffuse) coronary disease, severe calcific lesions, true bifurcation disease, left main coronary lesion, lesions with severe thrombus, and in-stent restenosis. Non-fatal intraprocedural complications included abrupt occlusion, worsening of thrombolysis in myocardial infarction (TIMI) flow grade (TIMI \< 3), major dissection (greater than type B), occurrence of thrombus formation, perforation of the main vessel or side branch, malignant arrhythmias, stroke/transient ischemic attack, and non-coronary major bleeding.

Interventions

None listed

Sponsors

Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Lead SponsorOTHER_GOV
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
CollaboratorOTHER_GOV
Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
CollaboratorOTHER
Istanbul Training and Research Hospital
CollaboratorOTHER_GOV
Sisli Hamidiye Etfal Training and Research Hospital
CollaboratorOTHER
Bagcilar Training and Research Hospital
CollaboratorOTHER_GOV
Ankara Etlik City Hospital
CollaboratorOTHER_GOV
Ankara Bilkent Sehir Hastanesi
CollaboratorOTHER
Bursa City Hospital
CollaboratorOTHER_GOV
Ege University
CollaboratorOTHER
Kocaeli University
CollaboratorOTHER
Trakya University
CollaboratorOTHER
Van Training and Research Hospital
CollaboratorOTHER_GOV
Cigli Regional Training Hospital
CollaboratorOTHER
Istanbul University - Cerrahpasa
CollaboratorOTHER
University of Yalova
CollaboratorOTHER
Bursa Yuksek Ihtisas Training and Research Hospital
CollaboratorOTHER_GOV

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

* Patients with complex coronary disease * Aged 18-85 years

Exclusion criteria

* Patients diagnosed with cardiogenic shock * Coronary lesions with non-complex features * Percutaneous coronary intervention with a bare metal stent * Patient life expectancy \<1 year * Known relevant allergies * Absence of all medical records * Patients with early discontinuation of dual antiplatelet therapy

Design outcomes

Primary

MeasureTime frameDescription
Deathup to 60 monthsAll cause death

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 10, 2026