A Retrospective Cohort Study of Patients Who Underwent Curative-intent Esophagectomy for ESCC at a Tertiary Referral Center in South Korea

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07201571

Enrollment

3131

Registered

2025-10-01

Start date

1994-11-06

Completion date

2025-08-31

Last updated

2025-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oesophageal Squamous Cell Carcinoma

Keywords

Oesophageal Squamous Cell Carcinoma, Esophagectomy

Brief summary

This retrospective cohort study was conducted using the Registry for Thoracic Cancer Surgery at Samsung Medical Center (Seoul, South Korea), which has included all patients who underwent thoracic surgery

Detailed description

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients who underwent curative surgery for esophageal cancer

Exclusion criteria

* cervical esophageal cancer * gastroesophageal junction cancer * histology other than squamous cell carcinoma * patients with Child-Pugh class B or C liver cirrhosis

Design outcomes

Primary

Measure	Time frame	Description
Postoperative complications	within 90 days after surgery	Complications related to fluid imbalance and portal hypertension, such as ascites, pleural effusion, and chyle leak; complications associated with impaired renal or hematologic function, including acute kidney injury, bleeding, and graft failure; and complications reflecting immune dysfunction and infection susceptibility, including pneumonia and empyema. Complications associated with impaired tissue healing, such as anastomotic leakage, were also analyzed. Liver failure and acute respiratory distress syndrome were considered separately. All complications were defined according to the Esophageal Complications Consensus Group, and their severity was assessed according to the Clavien-Dindo classification.

Secondary

Measure	Time frame	Description
Overall survival	10 years after surgery	Interval from the date of surgery to death or censoring

Outcome results