Necrotizing Pancreatitis
Conditions
Brief summary
The purpose of this retrospective study was to characterize the changes in organ dysfunction among patients with acute necrotizing pancreatitis complicated by sepsis who underwent open necrosectomy.
Detailed description
Baseline demographic and clinical characteristics (including age, gender, and education level) were collected from medical records. Organ dysfunction was defined according to the Sequential Organ Failure Assessment (SOFA) score. SOFA scores were extracted at predefined time points: preoperative (T1), postoperative day 1 (T2), postoperative day 3 (T3), and either postoperative day 7 or hospital discharge, whichever occurred first (T4). Postoperative survival status up to 1 year was obtained from the institutional database.
Interventions
OTHERNecrotizing Pancreatitis patients' organdysfunction progression
Study the dynamic nature of organ dysfunction
Sponsors
West China Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients 18 years or older 2. Diagnosis of Acute pancreatitis according to the revised Atlanta classification, requires two of thefollowing three criteria: (A) typical abdominal pain, (B) an increase in serum amylase or lipaselevels higher than three times the upper limit of normality, and (C) signs of AP in imaging3)Patients with confirmed or suspected infected pancreatic or peripancreatic necrosis werescheduled for open necrosectomy 3. Meet Sepsis-3 criteria
Exclusion criteria
Patients undergo repeat surgery on the same site
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure organ dysfunction change after open necrosectomy with respect to time | up to postoperative day 7, or at hospital discharge, whichever comes first | Organ dysfunction was assessed retrospectively using the Sequential Organ Failure Assessment (SOFA) score, which ranges from 0 (normal) to 4 (most abnormal) for each organ, with higher scores indicating more severe dysfunction. |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hospital mortality | an average of 1 year |
| Incidence of 28-day mortality | an average of 1 year |
| Incidence of ICU mortality | an average of 1year |
| ICU length of hospital stay | an average of 1 year |
| Length of hospital stay | an average of 1 year |
| Incidence of one year mortality | an average of 1 year |
Countries
China
Contacts
Primary ContactChunling Jiang, PhD
Outcome results
None listed