Sickle Cell Disease, Vaso-occlusive Crisis
Conditions
Keywords
Pediatric, Sickle Cell Anemia, Incidence, Outcomes
Brief summary
This study aims to assess the incidence and clinical outcomes of vaso-occlusive crises in pediatric patients with sickle cell disease. Data will be collected and analyzed to identify risk factors and related complications.
Detailed description
Sickle cell disease is a hereditary blood disorder characterized by the presence of sickle-shaped red blood cells, which leads to recurrent vaso-occlusive crises (VOC). These painful episodes are among the most common causes of hospitalization and are associated with significant morbidity in pediatric patients. Despite ongoing improvements in the management of sickle cell disease, there is still limited data describing the incidence, risk factors, and clinical outcomes of VOC in children within our population. This study is designed to retrospectively analyze medical records of pediatric patients with sickle cell disease at Faculty of Medicine, Assiut University. The primary aim is to estimate the incidence of vaso-occlusive crises and to identify the most frequent complications. Secondary objectives include evaluating treatment approaches, length of hospital stay, and clinical outcomes. Findings from this study are expected to provide valuable insights that may help improve clinical care strategies and preventive measures for affected children.
Interventions
OTHERNo intervention
retrospective observational study. No intervention will be administered; data will be collected from existing medical records of pediatric sickle cell patients at Assiut University Hospital.
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Children aged 1-18 years. Confirmed diagnosis of sickle cell anemia by hemoglobin electrophoresis or high-performance liquid chromatography . History of at least one hospital visit or admission for vaso-occlusive crisis
Exclusion criteria
* Patients with other hemoglobinopathies (e.g., thalassemia). Patients with incomplete medical records. Children with coexisting chronic diseases that may confound pain crises .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of vaso-occlusive crisis in pediatric sickle cell patients | Retrospective review of medical records from 2019 to 2024 | Frequency of vaso-occlusive crisis episodes will be identified through retrospective chart review of pediatric sickle cell patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complications associated with vaso-occlusive crisis (e.g., acute chest syndrome, stroke, infections) | Throughout the study period (2019-2024) | Complications related to vaso-occlusive crisis will be identified and documented from patient records. |
Countries
Egypt
Contacts
Primary ContactNadia Fawzy, Pediatrician
Backup ContactAssiut University research office
Outcome results
None listed