Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

Comparison Between Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07200817

Enrollment

290

Registered

2025-10-01

Start date

2024-09-20

Completion date

2026-03-19

Last updated

2025-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intensive Care Unit, Neutrophils to Lymphocytes, Platelets, Procalcitonin, Prognostic Outcome, Septic Patients, Total Leucocytic Count

Brief summary

This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.

Detailed description

Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients. Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied. The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.

Interventions

DIAGNOSTIC_TESTNeutrophils to Lymphocytes and Platelets ratio (N/LP)

The Neutrophils to Lymphocytes and Platelets ratio (N/LP) will be measured

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Age from 18 to 70 years old. * Both sexes. * Septic patients (under the third international consensus definitions of sepsis and septic shock).

Exclusion criteria

* Pregnancy * Malignancy * On immunosuppressive therapy * Hematological Disorders * Major Trauma * Major Burns * Child-Pugh Class C Liver Cirrhosis * On Hemodialysis

Design outcomes

Primary

Measure	Time frame	Description
Levels of Neutrophils to Lymphocytes and Platelets ratio	28 days post-procedure	The ratio of neutrophils to Lymphocytes and Platelets in relation to 28-day mortality among septic patients will be recorded.

Secondary

Measure	Time frame	Description
Procalcitonin (PCT)	28 days post-procedure	Procalcitonin (PCT) in relation to 28day mortality among septic patients will be recorded.
Total Leukocytic Count (TLC)	28 days post-procedure	Total Leukocytic Count (TLC) in relation to 28day mortality among septic patients will be recorded.

Countries

Egypt

Contacts

Primary ContactMichael G Farag, Master

MICHAELFARAG@med.asu.edu.eg00201278142328

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026