Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients

Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients: a Single-center Prospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07198308

Enrollment

Registered

2025-09-30

Start date

2025-10-01

Completion date

2026-03-13

Last updated

2026-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperglycemia

Brief summary

Heart rate variability (HRV) is a simple way to check how well the body's automatic nervous system is working. It does this by looking at how the heart rate changes in the electrocardiogram. HRV can be divided into time domain and frequency domain. Time domain indicators assess the tone of the autonomic nerves. Frequency domain indicators reflect the regulation of the sympathetic and parasympathetic nerves. An imbalance of the body's nervous system can be reflected by HRV. Stress hyperglycemia (SIH) is when your blood glucose levels go up because of an acute disease. This is usually related to the body's stress response, but if your blood glucose levels go up too much, it can lead to complications. A high blood sugar level caused by stress is common in intensive care units. There is a strong link between this and the death rate and how long patients stay there. There are lots of nerve endings in the pancreas. Nerve fibres control the way islet α/β cells work to keep the right amount of glucose in the blood. We know that the pancreatic nerve is important for controlling blood glucose levels, but we don't fully understand how it does this.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Inclusion criteria

* Aged from 18 to 99 years old * Informed consent has been signed

Exclusion criteria

* Under 18 years old * Diagnosed with diabetes either prior to or during hospitalization * Missing HRV values * Missing blood glucose and random insulin values

Design outcomes

Primary

Measure	Time frame
Correlation between glucagon and HRV in non-diabetic critically ill patients	From enrollment to completion of indicator testing (within 24 hours)

Secondary

Measure	Time frame
The correlation between blood glucose and random insulin levels and HRV in non-diabetic critically ill patients	From enrollment to completion of indicator testing (within 24 hours)

Countries

China

Outcome results