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CYFIP1 and PKM2 Synergistically Regulate ROS and Glycolysis in Colorectal Cancer Through the AKT/mTOR/HIF-1α Cascad

CYFIP1 and PKM2 Synergistically Regulate ROS and Glycolysis in Colorectal Cancer Through the AKT/mTOR/HIF-1α Cascad

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07197151
Enrollment
32
Registered
2025-09-29
Start date
2022-08-01
Completion date
2025-09-01
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer (CRC), Specimens Are to be Collected From Subjects Who Are Having or Have Had a Fluid or Tissue Removed, a Biopsy or a Blood or Bone Marrow Draw

Brief summary

Collect some tumor tissue specimens from patients who have undergone colorectal cancer surgery and conduct experiments such as immunohistochemistry to observe the expression of related genes in colorectal cancer.

Detailed description

We need to collect postoperative specimens and adjacent normal tissue specimens from patients with colorectal cancer for immunohistochemical staining. There is no need to conduct any other grouping of the patients.

Interventions

OTHERPerform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimens

Perform surgery on patients with colorectal cancer and collect cancer and adjacent tissue specimens

Sponsors

hui hou
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
OTHER

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

(1) Patients diagnosed with colorectal cancer who received surgical treatment and postoperative chemotherapy (2) Patients who were conscious of their condition and voluntarily participated (3) No other serious underlying diseases

Exclusion criteria

(1) Concurrent other serious chronic diseases or organ damage (2) Diagnosed with benign colorectal tumors

Design outcomes

Primary

MeasureTime frame
Immunohistochemical determination of the expression levels of related genes2022.09-2025.09

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026