Cancer, Cardiovascular Diseases, Death, Endocrine System Diseases, Respiratory Tract Diseases
Conditions
Brief summary
To further explore the application prospects of integrated Traditional Chinese and Western medicine in chronic disease prevention and control and health management, this study intends to establish a large, prospective, integrated Traditional Chinese and Western medicine cohort in Hubei Province. This study will conduct long-term follow-up and multi-dimensional data collection to systematically reveal the associations between Traditional Chinese Medicine (TCM) constitution types and chronic diseases, the aging process, and multi-morbidity, thereby developing an integrated health management strategy with local characteristics. This study will fill the current gap in systematic evidence linking TCM constitutions to the prevalence of modern diseases, providing a solid demographic and biological foundation for the integrated development of Traditional Chinese and Western medicine. It will also contribute to meeting the needs for early disease warning, early intervention, and personalized care under the Healthy China strategic goal.
Interventions
None listed
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hubei College of Traditional Chinese Medicine
Hubei Hospital of Traditional Chinese Medicine
Hubei Provincial Center for Disease Control and Prevention
Wuhan Center for Disease Control and Prevention
Huazhong University of Science and Technology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 74 Years
Healthy volunteers
Yes
Inclusion criteria
Age: Participants aged 30 to 74 years Physical Functionality: Free from severe physical disabilities impacting mobility or communication, with preserved ability to comprehend and respond to study procedures Informed Consent: Capable of providing written informed consent voluntarily after receiving full study disclosure
Exclusion criteria
Residents living in functional areas (e.g., work sheds, military units, student dormitories, nursing homes, etc.) Individuals unable to communicate normally
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prospective Cohort of Integrated Traditional Chinese and Western Medicine in China | From enrollment to the 10-year follow-up |
| Incidence of major chronic diseases (coronary heart disease, stroke, diabetes, COPD, lung cancer, colorectal cancer, gastric cancer, liver cancer, and esophageal cancer) | From baseline (enrollment) to 10-year follow-up Measurement Tool: Standardized physician-adjudicated diagnosis based on ICD-10 codes, confirmed through hospital electronic medical records and disease registries |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | From baseline to 10-year follow-up | Time Frame: From baseline to 10-year follow-up Measurement Tool: Death registry linkage and hospital records Unit of Measure: Mortality rate per 1,000 person-years |
Other
| Measure | Time frame | Description |
|---|---|---|
| Cause-specific mortality (cardiovascular, cancer, respiratory, metabolic) | From baseline to 10-year follow-up | Time Frame: From baseline to 10-year follow-up Measurement Tool: Death registry and ICD-10 coded cause of death Unit of Measure: Mortality rate per 1,000 person-years |
| Prevalence and progression of multimorbidity (≥2 chronic conditions) | Baseline to 10-year follow-up | Time Frame: Baseline to 10-year follow-up Measurement Tool: Questionnaire survey and physician-adjudicated diagnosis using ICD-10 Unit of Measure: % of participants with multimorbidity |
Outcome results
None listed