Symptomatic Irreversible Pulpitis (SIP)
Conditions
Keywords
pulpotomy, regenerative pulpotomy, ascorbic acid-augmented PRF, tannic acid crosslinked-PRF
Brief summary
The current study aims to assess the influence of different scaffolds on postoperative pain and success rate of pulpotomy in mandibular mature molars with symptomatic irreversible pulpitis
Detailed description
The study aims to assess different scaffolds used in regenerative pulpotomy of mature permanent mandibular first molars diagnosed with symptomatic irreversible pulpitis and their influence on postoperative pain and clinical and radiographic success rate of pulpotomy. It also aims to correlate the level of inflammatory mediators in pulpal blood to the success rate of pulpotomy.
Interventions
PROCEDURERegenerative pulpotomy
Regenerative pulpotomy combines the use of hydraulic calcium silicate based cements; MTA, together with biodegradable scaffolds such as PRF.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* ASA I patients who are free from any physical or mental handicapping condition with no underlying systemic disease. * Age between 15-40 years. * Males \& Females. * Patients' acceptance to participate in the trial. * Patients who can understand pain scale and can sign the informed consent (Appendix I). * Mature mandibular fist molars: * Diagnosed clinically with symptomatic irreversible pulpitis and normal periapical tissue. * Giving a positive response to pulp sensitivity testing. * Having negative response to percussion. * Having normal radiographic appearance of periapical tissues. * Having bright red color of pulp tissue, with hemorrhage control within 10 mins, upon access cavity preparation.
Exclusion criteria
* Pregnant and lactating females. * Patients with physical or mental handicapping conditions. * Patients unwilling to participate in a 12-months follow up. * Mandibular first molars with: * Immature roots. * Negative response to pulp sensitivity testing. * Positive response to percussion. * Radiographic evidence of periapical lesions, external or internal root resorption, vertical root fracture, or calcification. * Intraoral swelling or fistula. * Lack of pulpal bleeding, or inability to achieve hemostasis of the bleeding pulp within 10 mins, upon access cavity preparation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intensity of postoperative pain | 6, 12, 24, and 72 hours postoperatively | measured using numerical rating scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall success rate | 1, 3, 6, 9 and 12 months postoperatively. | Based on clinical and radiographic signs and symptoms |
| IL-8 and TNF-α levels in pulpal blood | Upon access cavity preparation | — |
Countries
Egypt
Contacts
CONTACTOmnia A Hakim, Assistant lecturer
Outcome results
None listed