Compensatory Hyperhidrosis, Compensatory Sweating
Conditions
Keywords
compensatory, hyperhidrosis, sympathectomy
Brief summary
The goal of this study is to compare the proportion of compensatory hyperhidrosis patients after sympathectomy at T3 level and sympathectomy at T3-4 level. The main question it aims to answer is: can sympathectomyv at one level decrease the incidence of compensatory hyperhidrosis after primary hyperhidrosis.
Detailed description
Primary hyperhidrosis is a chronic condition characterized by excessive sweating beyond physiological needs, commonly affecting the palms, axillae, face, or soles. This disorder is largely attributed to neurogenic hyperexcitability within the sympathetic nervous system's pathways innervating the eccrine sweat glands.When conservative treatments such as topical agents or oral medications fail, endoscopic thoracic sympathectomy (ETS) is considered an effective surgical option. However, a major postoperative complication is compensatory hyperhidrosis (CH)-the development of excessive sweating in previously unaffected areas such as the trunk, back, or thighs. CH can significantly impact patient satisfaction and quality of life, often becoming more distressing than the original condition. The extent and level of sympathectomy have been proposed as key factors influencing the incidence and severity of CH. While higher levels or multilevel resections (e.g., T2-4) are associated with increased rates of CH, more limited approaches such as T3-only resection are thought to reduce this risk. However, definitive evidence comparing T3 versus T3-4 sympathectomy remains limited and inconsistent across studies. This study aims to compare the incidence and severity of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy for primary hyperhidrosis. Understanding these differences may help refine surgical approaches to minimize CH and improve patient outcomes.
Interventions
None listed
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with primary hyperhidrosis * Patients with palmar and\\or axillary hyperhidrosis. * Age ≥ 6 years
Exclusion criteria
* History of Prior thoracic surgery. * History of prior disorder that cause hyperhidrosis ( obesity,autonomic neuropathy,menopause,gout,etc…) * History of prior systemic diseases cause hyperhidrosis (hyperthyroidism,DM,pheochromocytoma,Parkinson's disease,etc…) * Patients with psychological problems.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence of compensatory hyperhidrosis following T3 versus T3-4 sympathectomy. | 1 year post-sympathectomy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| severity of Compensatory hyperhidrosis by hyperhidrosis disease severity scale | 1 year post sympathectomy | 1. The sweating is never noticeable and doesn't interfere with daily activities. 2. The sweating is tolerable but sometimes interferes with daily activities. 3. The sweating is barely tolerable and frequently interferes with daily activities. 4. The sweating is intolerable and always interferes with daily activities. |
| recurrence rates of primary hyperhidrosis | 1 year post sympathectomy | — |
| site of compensatory hyperhidrosis | 1year post sympathectomy | — |
Outcome results
None listed