Balance, Excitability, Motor Cortex, Motor Skills Disorders, Parkinson Disease
Conditions
Brief summary
This study aimed to investigate the effects of rTMS on balance performance and functional mobility in people with PD. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on balance performance and functional mobility.
Interventions
DEVICErTMS
Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, balance performance, functional mobility, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.
Sponsors
Chung Shan Medical University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with primary Parkinson's disease 2. Age: 40-85 years 3. Hoehn and Yahr scale (H\&Y scale) : I-III 4. Appropriate prescribed medication, and regular intake for more than 2 weeks 5. Can walk more than 10m with or without the use of assistive devices
Exclusion criteria
1. Any other neurological presentation (Excluding PD) 2. Any neurological surgery that would affect participation in this experiment 3. Orthopedic pathology and Cardiovascular issues 4. MMSE≦24 5. Exercise used for treatment in the last three months 6. Contraindications for transcranial magnetic stimulation (Presence of metal implants in the head and neck, a pacemaker in the chest, personal or family history of epilepsy, recent brain injury, currently taking antidepressant medication.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dynamic balance | FRT will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period. | Functional Reach Test |
| Functional mobility | TUG will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period. | Timed Up and Go test |
| Motor function | UPDRS-III will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period. | UPDRS-III |
Countries
Taiwan
Contacts
STUDY_CHAIRLIU HSIN-HSUAN, PhD
Assistant Professor
PRINCIPAL_INVESTIGATORHONG SONG-PING, BSc
student
Outcome results
None listed