Acute Kidney Injury, Critical Illness, Severe Burns
Conditions
Keywords
Continuous Renal Replacement Therapy, RIFLE Criteria, Mortality, Hospital Length of Stay, Mechanical Ventilation, İnotropic Support
Brief summary
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.
Detailed description
Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined. In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors. By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.
Interventions
None listed
Sponsors
Pinar Timur Tasci
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 years and older * Admitted to and treated in the Burn Intensive Care Unit
Exclusion criteria
* Patients with an ICU stay of less than 24 hours * Patients younger than 18 years * Patients with known chronic kidney disease or history of kidney transplantation * Patients admitted with toxic epidermal necrolysis (TEN) * Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| RIFLE criteria classification at CRRT initiation | Baseline( Day0, at CRRT initiation) | Patients receiving CRRT will be classified according to the RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease) at the time of CRRT initiation. The distribution across categories will be analyzed. |
| Timing of CRRT initiation | Baseline( Day0, at CRRT initiation, recorded from patient medical records) | Date and time of initiation of continuous renal replacement therapy (CRRT), obtained from patient medical records. |
| Survival status of patients | At hospital discharge ( end of hospitalization) | Survival versus non-survival status at the end of hospitalization. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Presence of comorbidities in non-survivors | Baseline( Day0, at hospital admission) | Documentation of chronic comorbidities (e.g., diabetes, hypertension, cardiovascular disease) in patients who died after CRRT. |
| Hospital length of stay in non-survivors | From hospital admission through study completion( up to discharge or death) | Total length of hospitalization measured in days for patients who did not survive after CRRT. |
| Requirement for mechanical ventilation in non-survivors | Through ICU stay, up to hospital discharge (or death) | Need for invasive mechanical ventilation among non-survivors receiving CRRT. |
| Requirement for inotropic support in non-survivors | Through ICU stay, up to hospital discharge or death | Requirement for vasopressor or inotropic agents among non-survivors receiving CRRT. |
Countries
Turkey (Türkiye)
Outcome results
None listed