Pleural Infection
Conditions
Keywords
pleural infection, neutrophils, neutrophil extracellular traps, NETs, inflammation
Brief summary
Pleural infection is a severe and complicated disease which is associated with significant morbidity and mortality. People with pleural infection show diverse levels of neutrophil degranulation activity. The investigators examined the biological role of pleural fluid neutrophil extracellular traps in patients with pleural infection. TORPIDS-3 is an observational, International multicohort study.
Interventions
None listed
Sponsors
University of Dundee
University of Oxford
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients were included if they had a clinical presentation consistent with pleural infection as stated in the Methods section of the main manuscript and any of the following criteria: 1. Pleural fluid that was macroscopically purulent, OR 2. Pleural fluid that was positive on culture for bacterial infection, OR 3. Pleural fluid that demonstrated bacteria on Gram staining, OR 4. Pleural fluid with pH ≤7.2 (measured in a blood gas analyser) or low glucose level (≤3mmol/L or ≤55mg/dL) in a patient with clinical evidence of infection, OR 5. Contrast-enhanced CT evidence of pleural infection (consolidation of underlying lung with enhancing pleural collection) in a patient with clinical evidence of infection, alongside exclusion of other sources of infection.
Exclusion criteria
1. Age less than 18 years, OR 2. No pleural fluid available for analysis, OR 3. Patient previous pneumonectomy on the side of pleural infection, OR 4. Expected survival less than three months due to co-morbid disease, as judged by the recruiting physician
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disease severity | Baseline | Association between pleural fluid NETs with disease severity |
| One-year mortality | Baseline | Association between pleural fluid NETs and risk of one-year mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bacterial profiles | Baseline | Association between pleural fluid NETs with bacterial profiles |
| Sonographic septations | Baseline | Association between pleural fluid NETs and the presence of sonographic septations |
| Need for Intrapleural Enzyme Therapy (IET) | Baseline | Association between pleural fluid NETs with the requirement for IET |
Countries
United Kingdom
Outcome results
None listed