Ischaemic Heart Diseases
Conditions
Keywords
Ischaemia reperfusion, Gap junctions, Endothelial function
Brief summary
Arterial occlusion can lead to tissue ischemia and, if prolonged, end organ infarction. Clinical and experimental data would suggest that restoration of blood flow might trigger additional injury beyond that induced by the ischemia alone, so called Ischemia Reperfusion (IR) injury. IR injury impairs endothelial function through a mechanism that may involve intercellular gap junctions. Rotigaptide (ZP-123) is an anti-arrhythmic drug promoting intercellular coupling by increasing gap junction conductance. We intend to test the hypothesis that rotigaptide protects the forearm arterial circulation from IR-induced endothelial dysfunction.
Interventions
PROCEDUREForearm vascular study
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of vasodilators (Ach). Venous blood sampling via cannula in antecubital fossa.
Sponsors
University of Aarhus
University of Oxford
University of Edinburgh
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy males between 18-65 years of ages, non-smokers.
Exclusion criteria
* Any concurrent illness or chronic medical condition. Concurrent use of vasoactive medication. Smoking history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in forearm blood flow after ischaemia reperfusion with or without co-infusion of Rotigaptide | 20 fixed timepoints throughout the study up to 4 hours |
Countries
United Kingdom
Outcome results
None listed