Computed Tomography, CT Scan
Conditions
Brief summary
The goal of this clinical trial is to learn if a new computed tomography (CT) lung perfusion imaging method is as effective as standard of care (SOC) CT imaging. The main question it aims to answer is: * Does the new contrast-free method provide more information about lung perfusion than SOC? Participants will undergo a 30 minute chest CT.
Detailed description
The purpose of the study is to evaluate X-ray Pulsatility Index using prospectively acquired dynamic CT, which is different from conventional static CT scans. The primary objective of this study is to collect dynamic CT scan data with human participants using high frame rate imaging methods to produce a map of lung perfusion.
Interventions
DIAGNOSTIC_TESTCT scan
Dynamic contrast-free chest CT scan
Sponsors
University of Wisconsin, Madison
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years or older * Able to sign and date the informed consent form * Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities
Exclusion criteria
* Pregnant or lactating * In need of urgent or emergent care * Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lung x-ray pulsatility index (XPI) | 30 minutes | XPI, a representative of lung perfusion, will be measured using CT images. The dynamic x-ray attenuation from each pixel is analyzed using spectral analysis. |
| Magnitude of XPI | 30 minutes | Measured as a number, this corresponds to the magnitude of the relative change of signal. |
| Presence of XPI | 30 minutes | This will be evaluated quantitatively using CNR (contrast to noise) measurements which uses a region of interest in the lungs and a region of interest outside of the lungs. |
| Spatial distribution of XPI signal | 30 minutes | This is a subjective evaluation, routinely done clinically with other modalities that measure lung perfusion. Researchers evaluate how homogenous (smooth) the signal is over the lungs and look for perfusion defects (areas with little or no XPI) which would indicate pathology. |
Countries
United States
Contacts
CONTACTRadiology Studies
PRINCIPAL_INVESTIGATORMatthew Smith, MD, PhD
University of Wisconsin, Madison
Outcome results
None listed