Intensive Care Unit Acquired Weakness, Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)
Conditions
Keywords
Critical Care, Intensive Care Units, Physical Therapy Department, Hospital, Muscle Weakness, Functional Status, Physical Functional Performance, Outcome Assessment, Health Care, Rehabilitation
Brief summary
This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx). The primary objective is to analyze CPAx score variation as a potential predictor of clinical outcomes, including mortality and duration of mechanical ventilation. Functional assessments will be performed at intensive care unit (ICU) admission and discharge to monitor changes in physical function and to predict adverse clinical outcomes.
Detailed description
This prospective, longitudinal, and observational study will be conducted at the general ICU of Pedro Ernesto University Hospital (HUPE). Demographic and clinical information at admission will be collected, including age, sex, type of airway at ICU admission, cause of ICU admission, comorbidities, and clinical scores such as Sepsis-related Organ Failure Assessment (SOFA), Simplified Acute Physiology Score III (SAPS III), and Charlson Comorbidity Index. During the ICU stay, data on the use of invasive mechanical ventilation, non-invasive ventilation, high-flow nasal cannula (HFNC), renal replacement therapy, extubation, and reintubation will be recorded. The CPAx will be assessed at ICU admission and discharge. Additionally, total hospital and ICU length of stay, as well as days on mechanical ventilation, will be recorded.The study aims to analyze the variation in CPAx scores as a predictor of adverse clinical outcomes, including mortality and duration of mechanical ventilation.
Interventions
None listed
Sponsors
Hospital Universitario Pedro Ernesto
Instituto Nacional de Infectologia Evandro Chagas
Universidade Federal do Rio de Janeiro
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
All adult patients admitted to the Pedro Ernesto University Hospital (HUPE) General ICU over 18 years of age and with an ICU stay greater than or equal to 48 hours will be included.
Exclusion criteria
* Pregnancy * Inability to record the CPAx score within the first 48 hours of ICU admission or on the day of ICU discharge * ICU readmission * Known comorbidities causing generalized weakness, such as neuromuscular or neurological diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| hospital mortality | 12 months | Mortality will be collected during the period of hospitalization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mechanical ventilation days | 6 months | It will be collected from the date of intubation in the intensive care unit until the date of extubation or up to 48 hours off mechanical ventilation in cases of tracheostomized patients and/or until the outcome of death |
| ICU length of stay | 6 months | It will be collected from the date of intensive care unit admission until the outcome of discharge from the intensive care unit or death. |
| length of hospital | 12 months | It will be collected from the date of intensive care unit admission until the outcome of hospital discharge or death. |
| Extubation rate | 30 days | Proportion of patients who were extubated during ICU stay. |
| Reintubation rate | 30 days | Proportion of patients who require reintubation after extubation during ICU stay. |
Countries
Brazil
Contacts
Primary ContactRAFAELA S PAIM
Backup ContactGABRIEL G MAIA, PhD
Outcome results
None listed