Inflammatory Responses After CrossFit and Resistance Trainings in Untrained Subjects

The Effect of a CrossFit Training Program on Physical, Physiological, and Hormonal Responses in Untrained Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07190924

Enrollment

Registered

2025-09-24

Start date

2021-11-08

Completion date

2022-04-17

Last updated

2025-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hormones, Inflammation, Oxidative Stress, Plasma Volume

Brief summary

Considering the remarkable increase of the fitness programs, the purpose of this study was to assess and compare the effect of Crossfit (CF) and periodized resistance (RT) trainings on inflammatory/oxidative responses in untrained individuals. Twenty-four participants (20 men and 4 women, age= 25.7 ± 2.2 years, BMI= 25.7 kg.m-2) were randomly assigned into 12 weeks of these trainings with a rate of five sessions/week. Before and after intervention, participants anthropometric data and graded exercise tests were performed. Before (pre), immediately after (post) and 60min after test (p60) a 20mL venous blood sample were drawn for a later measure of c-reactive protein (CRP), interleukin 1 beta (IL-1ß), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 10 (IL-10), thiobarbituric acid reactive substances (TBARS), antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx).

Interventions

BEHAVIORAL12 week training

Anti-inflammatory and oxidative environment following 12-weeks of CF training by evaluating inflammatory markers and oxidative precursors in untrained participants

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Participants must be non-smokers, * Participants should not suffer from respiratory issues * Participants should have healthy kidney and liver * Participants have no metabolic and neurological disorders

Exclusion criteria

* The use of medications during the previous 4 weeks * Consumption of any product related to anti-inflammatory/oxidative supplements

Design outcomes

Primary

Measure	Time frame	Description
Inflammatory marker	Participants data were performed in one day before beginning the 12 week intervention and one day after the last session	c-reactive protein (CRP),
Oxidative stress	Participants data were performed in one day before beginning the 12 week intervention and one day after the last session	thiobarbituric acid reactive substances (TBARS)

Countries

Tunisia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026