Ginger to Prevent Nausea and Vomiting After Laparoscopic Cholecystectomy

Preoperative Ginger for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: A Double-Blind Randomized Controlled Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07190495

Acronym

GINGER-PONV

Enrollment

102

Registered

2025-09-24

Start date

2025-07-05

Completion date

2026-12-01

Last updated

2026-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic Cholecystectomy, Postoperative Nausea and Vomiting

Keywords

Ginger, Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy

Brief summary

This study aims to evaluate whether preoperative oral administration of ginger (800 mg, given 2 hours before surgery) reduces the incidence and severity of postoperative nausea and vomiting (PONV) within the first 24 hours after laparoscopic cholecystectomy.

Interventions

DRUGGinger

Patients will receive 800 mg of oral ginger 2 hours before laparoscopic cholecystectomy

DRUGPlacebo

Patients will receive an oral placebo capsule identical in appearance to ginger, administered 2 hours before laparoscopic cholecystectomy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 18 years. * Scheduled for elective laparoscopic cholecystectomy under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I-III. * Able to understand the study procedures and provide written informed consent.

Exclusion criteria

* Known allergy or hypersensitivity to ginger * Documented history of bleeding disorders or current treatment with anticoagulant agents * History of severe postoperative nausea and vomiting or an Apfel score of 4 * Administration of antiemetic drugs or corticosteroids during the preoperative period * Pregnancy or breastfeeding * Active gastrointestinal or liver disease

Design outcomes

Primary

Measure	Time frame	Description
Incidence of postoperative nausea and vomiting (PONV) within 2 hours post-surgery	2 hours after surgery.	Occurrence of at least one episode of nausea or vomiting within the first 2 hours after surgery.

Secondary

Measure	Time frame	Description
Recurrence of PONV beyond 2 hours postoperatively	From 2 hours to 24 hours after surgery.	Proportion of participants who experienced at least one additional episode of nausea or vomiting occurring after the 2-hour postoperative time point.
Incidence of postoperative nausea and vomiting (PONV) within 24 hours post-surgery	24 hours after surgery.	Occurrence of at least one episode of nausea or vomiting within the first 24 hours after surgery.
Total number of vomiting episodes	Within 24 hours post-surgery.	Cumulative number of vomiting episodes recorded per participant during the first 24 hours after surgery.
Use of rescue antiemetics	24 hours postoperatively	The need for rescue antiemetics within 24 hours postoperatively.
Incidence of ginger-related adverse events	Within 24 hours after surgery	Number of participants experiencing adverse events known to be associated with ginger, including gastrointestinal discomfort (heartburn, abdominal pain, bloating, diarrhea), bleeding, or allergic reactions in the 24 hours after surgery.

Countries

Tunisia

Contacts

CONTACTIbtissem BEN TALEB, M.D.

ibtissem.bentaleb@fmt.utm.tn+216 23 133 748

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 29, 2026