Depression Bipolar, Depression - Major Depressive Disorder, Treatment Resistant Depression
Conditions
Keywords
Observational, Cohort, Depression, UK, Mission, Bipolar, TRD, Difficult-to-treat, Treatment resistant depression, Bipolar depression, cohort study, Observational study
Brief summary
The current study aims to understand why some people with depression respond to treatment and others do not, using markers of clinical symptoms, both clinician reported outcome measures and patient reported outcome measures, demographic information, cognitive function, genetic sequence information (genomic), chemical measures of metabolism (metabolomic), protein makeup (proteomic) and the body's natural defence system (immune/inflammatory markers) together with collections of cells that will facilitate new research to drive improvements in diagnosis and treatment of mood disorders that may be proving difficult to treat. This will allow future clinical trials within the NHS, academia and industry to drive forward new approaches and treatments. Participants who provide consent for re-contact for future treatment trials and other research studies have the potential to benefit from this with participation in experimental studies and clinical trials associated with improved patient outcomes. Overall, the cohort will generally support greater access to research opportunities for a wider population of people.
Interventions
None listed
Sponsors
Newcastle University
University of Nottingham
University of Exeter
University of Southampton
University of Birmingham
University of Manchester
University of Liverpool
Avon and Wiltshire Mental Health Partnership NHS Trust
Cambridgeshire and Peterborough NHS Foundation Trust
University of Cambridge
Cardiff University
Cardiff and Vale University Health Board
University of Edinburgh
University of Glasgow
University College, London
Sheffield Health and Social Care NHS Foundation Trust
King's College London
Imperial College London
Oxford Health NHS FT
Cumbria, Northumberland, Tyne and Wear NHS FT
South London and Maudsley NHS FT
Nottinghamshire Healthcare NHS FT
Devon Partnership Trust
Hampshire and Isle of Wight Health NHS FT
Birmingham and Solihull Mental Health NHS Trust
Mersey Care NHS FT
NHS Lothian
NHS Greater Glasgow & Clyde
Camden & Islington NHS FT
West London NHS FT
Central and North West London NHS FT
University of Oxford
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Those aged 18 and above * Primary clinical diagnosis of MDD or bipolar disorder based on DSM-5/ICD-11 diagnostic criteria * Participant is willing and able to give informed consent for participation in the study * Possesses sufficient command of the English language required to complete study requirements, as assessed by the study team
Exclusion criteria
* Inability to complete study activities as assessed by the study team * Presentation requires immediate emergency treatment * Presentation requires clinical input not available within the research clinic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PHQ-9 | Up to 36 months. | Patient Health Questionnaire - 9-item Depression scale. Scores range between 0-27, with higher scores indicating worse depression. |
Other
| Measure | Time frame | Description |
|---|---|---|
| GAD-7 | Up to 36 months. | Generalised Anxiety Disorder Questionnaire - 7 item. Scores range between 0-21, with higher scores indicating worse anxiety. |
Countries
United Kingdom
Contacts
Primary ContactAlexander Lewis
Backup ContactProfessor Michael Browning
Outcome results
None listed