Cirrhosis With Hepatocellular Carcinoma
Conditions
Brief summary
The main purpose of the study is to characterize the production of hepatokines (FGF21 and Follistatin) in response to a submaximal exercise on an ergocycle, in patients with hepatocellular carcinoma. The effect of exercise on hepatokines and metabolites production in liver cancer patients is not known. Studying this production could help to provide relevant recommendations for training programming in these patients.
Interventions
OTHERExercise
30-minutes exercise on a bicycle with heart rate monitor and gas exchange analyzer.
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Hepatocellular carcinoma developed on cirrhosis * Cirrhosis of any etiology, defined by a liver elasticity measurement \>15kPa or a history of cirrhosis decompensation * Hepatocellular carcinoma with indication for treatment by immunotherapy or chemoembolization * Child-Pugh scores A and B7 * WHO score ≤ 2 * Affiliation to french national social security system
Exclusion criteria
* Hepatic encephalopathy grade II or higher * Bone metastasis * Surgery performed within 30 days prior to inclusion visit * Liver transplant * Muscle injury within 3 months of inclusion * Pregnant or breast-feeding women * Patients under legal protection (guardianship, curatorship, safeguard of justice) * Participation in another clinical trial within 10 days of inclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systemic hepatokines rates (FGF-21 and follistatin) | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise | Blood samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle pain assessment | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise | Visual analog scale. Score from 0 (total absence of muscle pain) to 10 (maximum muscle pain). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Fatigue assessment | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise | Visual analog scale. Score from 0 (total absence of fatigue) to 10 (maximum fatigue). |
| Perception of effort assessment | Baseline (at the beginning), periprocedural (middle of exercise), immediately after exercise | Borg scale |
| Production of metabolites | Baseline (pre-exercise), immediately after exercise, 1 hour after the end of exercise | Blood samples |
Countries
France
Contacts
Primary ContactLise Laclautre
Outcome results
None listed