Anemia of Neonates, Hemolytic Disease of Newborn, Sepsis
Conditions
Brief summary
Risk Factors, and Clinical Outcomes of Neonatal Anemia in the NICU of a Tertiary Care Hospital
Detailed description
Neonatal anemia is one of the most common hematological problems encountered in neonatal intensive care units (NICUs), particularly among preterm and very low birth-weight (VLBW) infants. It is defined as a hemoglobin (Hb) or hematocrit (Hct) concentration below the normal range for gestational and postnatal age, often necessitating clinical intervention to ensure adequate tissue oxygenation and prevent long-term neurodevelopmental consequences Anemia: Hb \<13 g/dL in term newborns; Hb \<12 g/dL in preterm neonates within the first week of life, according to WHO criteria The pathophysiology is multifactorial, involving both physiological and pathological processes. In preterm neonates, the condition known as anemia of prematurity (AOP) is primarily characterized by reduced erythropoietin production, shortened red blood cell (RBC) lifespan, and rapid postnatal growth that increases iron demand Globally, over 80% of extremely preterm infants (\<28 weeks of gestation) require at least one RBC transfusion during their hospitalization . In Egypt, recent tertiary-level NICU data suggest that the prevalence of neonatal anemia among admitted preterm infants exceeds 60%, with many requiring multiple transfusions in the first month of life Major contributing factors include iatrogenic blood loss from frequent phlebotomy, insufficient iron stores at birth due to shortened gestation, hemolysis (immune or non-immune), and acute blood loss from perinatal events
Interventions
None listed
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 30 Days
Healthy volunteers
Yes
Inclusion criteria
* All live-born neonates admitted to the NICU within the first 24 hours of life. * Both term and preterm infants.
Exclusion criteria
* Major congenital malformations * Chromosomal abnormalities or genetic syndromes * Neonates with a previous blood transfusion before study enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Understanding the local prevalence, associated factors, and outcomes of neonatal anemia | 1 year | To determine the prevalence of neonatal anemia among neonates admitted to a tertiary care neonatal intensive care unit (NICU * To identify maternal, perinatal, and neonatal risk factors associated with neonatal anemia * To assess short-term outcomes, including length of hospital stay, need for blood transfusion, morbidity, and mortality |
Contacts
Primary ContactAli Harris
Outcome results
None listed