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Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer

Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer: A Historical Cohort Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07188116
Enrollment
200
Registered
2025-09-23
Start date
2025-09-15
Completion date
2025-12-31
Last updated
2025-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer, COVID-19, Radiation Pneumonia

Keywords

Retrospective Analysis, COVID-19, Radiation Pneumonitis, Propensity Score Matching, Breast Cancer

Brief summary

This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients.

Detailed description

This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients. Breast cancer patients who underwent radiotherapy at the Cancer Center of Zhejiang Hospital between January 1, 2021, and June 30, 2024, were screened for eligibility. Patients who met the inclusion criteria were identified through the hospital information system, and their clinical records were reviewed. Follow-up was conducted via telephone interviews.

Interventions

OTHERCOVID-19

The COVID-19 infection situation was used as an intervention measure, and the cohort was divided into groups.

Sponsors

Zhejiang Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

1. patients with pathologically or cytologically confirmed primary breast cancer, 2. aged 18 years or older but younger than 80 years, 3. with complete and reliable medical records, 4. for those with COVID-19 infection, documented evidence of a positive test result.

Exclusion criteria

1. concomitant pulmonary malignancies, 2. a history of prior thoracic radiotherapy, 3. concurrent pulmonary infections other than COVID-19 during radiotherapy, 4. missing key data with loss to follow-up, 5. or any other condition considered unsuitable for enrollment by the investigators.

Design outcomes

Primary

MeasureTime frameDescription
Radiation Pneumonitis SituationFrom January 2021 to June 2024The incidence rate, severity and onset time of radiation pneumonitis

Countries

China

Contacts

Primary ContactPengyuan Liu
oncologyliupengyuan@outlook.com18368846455

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026