Periodontitis, Adult
Conditions
Keywords
Nonsurgical therapy, local delivery gel, curcumin gel, ozonated olive oil, molar incisor pattern periodontitis, Chronic periodontitis, stage II grade B
Brief summary
The aim of this clinical trial is to evaluate the effectiveness of local delivery ozonated olive gel versus curcumin gel as adjunct to scaling and root planing in the treatment of stage II grade B periodontitis in on both males and females in the age group between 18 and 50 years. outcome measures are Clinical attachment level (CAL), plaque index (PI), gingival index (GI).
Detailed description
Periodontitis is an advanced periodontal disease with a distinctive clinical signs and symptoms as rapid attachment loss and bone destruction The primary treatment approach for periodontitis is mechanical plaque removal through debridement, particularly scaling and root planing (SRP) using hand or ultrasonic instruments. curcumin gel is an adjunct to non-surgical periodontal therapy is a highly potent local antioxidant and anti-inflammatory agent. While ozone has a potent antimicrobial and anti-inflammatory effects it also can be incorporated into a lipid carrier such as olive oil. Ozone's stability and ease of application are markedly enhanced. Ozonized olive oil can be formulated into a gel with ideal rheological properties for injection into periodontal pockets.
Interventions
PROCEDUREfull mouth non-surgical scaling
All patients will receive a full mouth scaling using ultrasonic scalers and hand instrumentation
Sponsors
Cairo University
MTI University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
The test group "Group 3" will receive full Scaling and root planing (SRP) followed by subgingival application of ozonated olive gel. The test group "Group 2" will receive full-mouth SRP followed by subgingival application of curcumin gel The control group "Group 1" will receive full-mouth SRP followed by subgingival application of placebo gel
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients diagnosed with stage II periodontitis defined by having interdental CAL 3-4 mm and presence of pocket depth (PD) ≤ 5 mm, and grade B periodontitis characterized by a moderate rate of disease progression. 2. Patients agree to a 3-month follow-up period and provide an informed consent.
Exclusion criteria
1. Presence of prosthetic crowns, overhanging restorations and orthodontic treatment. 2. Teeth with both endo-perio lesions. 3. Antibiotics therapy that has an impact on the clinical signs and symptoms of periodontitis in the previous 3 months. 4. Anti-inflammatory drugs in the previous 1 month. 6\. History of systemic disease, allergy, cardiovascular diseases, diabetes mellitus, hypertension, bleeding disorders, hyperparathyroidism, and compromised medical conditions, pregnant and lactating females.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical attachment level | 3 months | measured from the cementoenamel junction (CEJ) to the bottom of pocket. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gingival Index | 3 months | Index scores will be recorded showing gingival bleeding and inflammation |
| Plaque index | 3 months | be used to evaluate plaque accumulation |
Countries
Egypt
Contacts
PRINCIPAL_INVESTIGATORParryhan M Abdelsamie
MTI University
Outcome results
None listed