Cognitive Impairment, Frail Older Adults, Orthopaedic Surgery
Conditions
Keywords
cognitive frailty, neurofilament light chain, cerebrospinal fluid biomarkers, older adult patients, orthopedic surgery
Brief summary
this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery. The main questions it aims to answer is: * Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions? * Can these biomarkers be used as potential tools for early identification in vulnarable populations?
Detailed description
It is a cross sectional study
Interventions
BEHAVIORALassessment Mini mental state examination
pre operatively four weeks postoperatively
BEHAVIORALassessment FRAIL scale
pre operatively four weeks postoperatively
OTHERcollecting cerebrospinal fluid during regional anesthesia
In the operating room regional anesthesia was administered according to the surgical plan
Sponsors
Baskent University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ASA 1-3 patients * \>65 age patients
Exclusion criteria
* history of psychiatric or neurological disease * uncontrolled hypertension * alchohol dependence * renal failure * active liver disease * cancer-related or emergency surgery * unwillingness to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between biomarkers of neurodegeneration and preoperative frailty, cognitive function? | preoperatively and four weeks postoperatively | p\<0,05 was accepted as statistically significant |
Countries
Turkey (Türkiye)
Outcome results
None listed