Echocardiographic Assessment of Pulmonary Hypertension in Obstructive Sleep Apnea

A Prospective Observational Study on Pulmonary Hypertension in Patients With Obstructive Sleep Apnea: Correlation of Apnea-Hypopnea Severity With Pulmonary Artery Pressures

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07184060

Enrollment

Registered

2025-09-19

Start date

2025-10-30

Completion date

2027-08-30

Last updated

2025-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea (OSA), Pulmonary Hypertension

Keywords

obstructive sleep apnea, pulmonary hypertension

Brief summary

This study investigates the association between obstructive sleep apnea (OSA) and pulmonary hypertension (PH), focusing on the relationship between OSA severity and pulmonary arterial pressures in adult patients.

Detailed description

This prospective, observational, cross-sectional study will be conducted in the pulmonology and sleep medicine departments of Assiut University. Patients diagnosed with OSA through overnight polysomnography will be assessed for the presence and severity of PH using echocardiography. The study aims to determine whether OSA serves as an independent risk factor for PH and whether the severity of OSA, as measured by apnea-hypopnea index (AHI) and oxygen desaturation index (ODI), correlates with echocardiographic indicators of PH. Data will be analyzed using standardized statistical methods to establish links between OSA severity and hemodynamic changes.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Adults aged 18-65 years Diagnosed with obstructive sleep apnea (OSA) by full-night polysomnography Apnea-Hypopnea Index (AHI) ≥ 5 events/hour

Exclusion criteria

Secondary pulmonary hypertension due to:Chronic pulmonary diseases, Left ventricular heart disease and Chronic thromboembolic disorders Use of pulmonary vasodilator therapy Long-term oxygen therapy (LTOT) Respiratory neuromuscular weakness Chest wall deformities End-organ failure (cardiac, renal, hepatic) Malignancy Obesity hypoventilation syndrome

Design outcomes

Primary

Measure	Time frame	Description
Mean Pulmonary Artery Pressure	baseline	The primary objective is to assess the presence and degree of pulmonary hypertension (measured by echocardiography) in OSA patients.

Outcome results