Periodontal Bone Loss, Periodontal Disease, Platelet Rich Fibrin
Conditions
Brief summary
Objective: To evaluate clinically the long-term results following treatment of deep intrabony defects with either platelet-rich fibrin gel (PRF) or an enamel matrix derivative (EMD). Methods: Twenty six patients diagnosed with advanced chronic periodontitis, and each of whom displaying one deep intrabony defect were randomly treated with open flap debridement and with either PRF (test) or EMD (Emdogain, Straumann, Basel, Switzerland) (control). The clinical outcomes were evaluated at baseline, at six months and three years after treatment. The primary outcome variable was the clinical attachment level (CAL).
Interventions
OTHERPlatelet rich fibrin
Platelet-rich fibrin (PRF) was prepared according to the manufacturer's instructions. A blood sample was collected from the cubital vein in 10 ml tubes without anticoagulant and centrifuged at 3000 rpm for 10 minutes using a GLO GT416 table centrifuge (GLO Glotech Co. Ltd, Korea) and GLO PRP collection kit (GLO PRP-Kit, Glotech Co, Asan Choong-nam, Korea/ Glofinn, Finland).
In the control group, the root surface was conditioned with 24% ethylenediaminetetraacetic acid (EDTA) gel for two minutes, washed with physiological saline solution, dried, and treated with enamel matrix derivative (EMD), (Emdogain, Straumann, Switzerland) per manufacturer recommendations.
Sponsors
Semmelweis University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. No systemic conditions affecting treatment outcomes 2. Good oral hygiene \[plaque index (PI) \<1; Löe 1967\] 3. Compliance with the maintenance program 4. Presence of at least one intra-bony defect with a probing depth (PD) of ≥6 mm and an intra-bony component of ≥3 mm confirmed by radiographs.
Exclusion criteria
* significant medical conditions: irradiation in the maxillofacial area, uncontrolled diabetes or hypertension, systemic steroid or bisphosphonate treatment, pregnancy, or lactation, infectious diseases, * age \<18 years, (3) smokers (\>5 cigarettes/day), * high residual inflammation (FMBS \>25%), * poor oral hygiene (FMPS \>25%), and * defect-related factors: furcation involvement, endo-perio defects, horizontal defects, or multi-tooth defects .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing pocket depth (PPD) | preop and after 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Gingival recession | preop and after 6 months |
| Clinical attachment loss | preop and after 6 months |
Countries
Hungary
Outcome results
None listed