Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors

Dynamic Monitoring and Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07182175

Enrollment

150

Registered

2025-09-19

Start date

2024-09-19

Completion date

2026-05-29

Last updated

2025-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adrenal Tumor, Cushing s Syndrome, Pheochromocytoma/Paraganglioma (PPGL), Primary Aldosteronism

Brief summary

The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery. The main questions it aims to answer are: * What heart and blood pressure changes do patients with different types of adrenal tumors have before surgery? * What factors affect how the heart and blood pressure recover after surgery? * Do the heart and blood pressure conditions before surgery influence recovery and the risk of heart or brain problems after surgery? Patients will have heart ultrasound checks and health monitoring before and after surgery. The results will help doctors choose the right medicines before surgery, better understand possible risks during the operation, and make safer treatment plans for patients with functional adrenal tumors.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients diagnosed in the Department of Urology, Peking University First Hospital with pheochromocytoma and paraganglioma (PPGL), primary aldosteronism (PA), or Cushing syndrome (CS); * Written informed consent obtained.

Exclusion criteria

* Patients with PPGL, PA, or CS who receive medication or conservative treatment and are not eligible for surgical resection; * Patients with communication disorders or severe physical impairments such as aphasia, or visual/hearing disabilities; * Patients with severe mental illness who cannot cooperate with the study; * Pregnant women or patients otherwise deemed unsuitable for participation by the investigators.

Design outcomes

Primary

Measure	Time frame	Description
Recovery of cardiac function after adrenal surgery	from enrollment to 4,24,48 weeks after surgery	global longitudinal stress

Secondary

Measure	Time frame	Description
Recovery of blood pressure after adrenal surgery	from enrollment to 4,24,48 weeks after surgery	Decrease in 24h average blood pressure

Countries

China

Outcome results