Acute Myocardial Infarction
Conditions
Brief summary
At present, there are 290 million cardiovascular patients in China, including 11 million patients with coronary heart disease. Remote ischemic preconditioning(RIPC) may play an effective endogenous cardiac protection.This study will explore whether long-term use of RIPC in patients with AMI after PCI and non interventional therapy can reduce the incidence of major adverse cardiovascular cerebrovascular events(MACCE) and improve clinical outcomes and long-term prognosis.
Detailed description
A total of 2146 patients with AMI are expected included as the research objects and randomly divided into experimental group and control group with 1073 cases in each group. After admission, Patients in the experimental group received everyday RIPC of upper limbs to the end of follow-up.The control group is a blank control and undergoes conventional medical procedures. Routine blood indexes, ultrasound, electrocardiogram, were detected On the day of admission. 12 months post- discharge, the incidence of MACCE(include Cardiovascular death, non-fatal acute myocardial infarction, stent thrombosis, revascularization, stroke, admission due to heart failure and the above composite events were independent components) and Poce(All deaths, all strokes, all myocardial infarction, or all revascularization events)will recorded by telephone follow-up.
Interventions
OTHERRIPerC
Each 40 minutes treatment time, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles
OTHERRIPC
Each 40 minutes treatment time, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles
Sponsors
Henan Institute of Cardiovascular Epidemiology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Patients diagnosed with acute myocardial infarction on admission were immediately assigned to the experimental group and control group
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with acute myocardial infarction were diagnosed in accordance with the criteria of the Global Unified Definition of Fourth Myocardial Infarction
Exclusion criteria
* The patients could not tolerate RIPC or RIPerC * Aortic dissection, coronary artery aneurysm, coronary artery fistula and other systemic organic diseases * The uncontrolled systolic blood pressure and diastolic blood pressure of severe hypertension were 180 mmHg and 120 mmHg respectively * severe liver dysfunction (bilirubin \> 20 mmol / L, prothrombin time \> 2.0 ratio) * Severe renal insufficiency (GFR \< 30 ml / min / 1.73 m2); * patients taking nicorandil and other drugs affecting microcirculation * pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of MACCEs | 12 months after discharge | MACCE(include Cardiovascular death, non-fatal acute myocardial infarction, revascularization, stroke, admission due to heart failure ) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of non-fatal acute myocardial infarction events | 12 months after discharge | Rate of non-fatal acute myocardial infarction events |
| Rate of revascularization events | 12 months after discharge | Rate of revascularization events |
| Rate of Cardiovascular death events | 12 months after discharge | Rate of Cardiovascular death events |
| Rate of admission due to heart failure events | 12 months after discharge | Rate of admission due to heart failure events |
| Rate of all all-cause death events | 12 months after discharge | Rate of all all-cause death events |
| Rate of stroke events | 12 months after discharge | Rate of stroke events |
Countries
China
Contacts
Primary ContactMuwei LI
Backup ContactGUO QUAN
Outcome results
None listed